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Nature 447, 265-266 (17 May 2007) | doi:10.1038/447265a; Published online 16 May 2007
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- Brighams and Women's Hospital
- Boston, MA
Assistant / Associate Professor
- University of South Dakota - Biomedical Engineering
- 4800 N. Career Ave., Suite 118 Sioux Falls, SD 57107
Regenerative biology: New hair from healing wounds
Cheng-Ming Chuong1
Abstract
In mammals, most wounds heal by repair, not regeneration. It now seems that, as they heal, open skin wounds in adult mice form new hair follicles that follow similar developmental paths to those of embryos.
A person whose leg is amputated is left with a stump, whereas some amphibians have the awe-inspiring ability to regenerate new limbs after amputation. Overall, adult mammals have very limited regenerative ability; this could be due to a lack of stem cells or the absence of proper environmental signals.
- Cheng-Ming Chuong is in the Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Email: chuong@pathfinder.usc.edu
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RESEARCH
An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell ContributionJournal of Investigative Dermatology Original Article
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Wnt-dependent de novo hair follicle regeneration in adult mouse skin after woundingNature Letters to Editor (17 May 2007)
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