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Nature 447, 951-958 (21 June 2007) | doi:10.1038/nature05980; Published online 20 June 2007
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Review Article Chromatin dynamics and the preservation of genetic information
Jessica A. Downs1, Michel C. Nussenzweig2 & André Nussenzweig3
Abstract
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.
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