Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 447, 951-958 (21 June 2007) | doi:10.1038/nature05980; Published online 20 June 2007
Open Innovation Challenges
- More Challenges
- Powered by:
nature jobs
Senior Researcher in theoretical chemistry / physics
- Italian Institute of Technology
- Lecce, Italy
Post Doctoral Positions
- University of Saskatchewan
- Saskatchewan, Canada
Review Article Chromatin dynamics and the preservation of genetic information
Jessica A. Downs1, Michel C. Nussenzweig2 & André Nussenzweig3
Abstract
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Tip60-ing the balance in DSB repairNature Cell Biology News and Views (01 Nov 2009)
The bromodomain: a chromatin-targeting module?Nature Structural Biology News and Views (01 Jul 1999)
