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Nature 449, 835-842 (18 October 2007) | doi:10.1038/nature06248; Published online 17 October 2007
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Bacterial Geneticist / Microbiologist
- TCG Lifesciences Ltd
- Kolkata India
Manager (Department : Patents)
- Piramal HealthCare
- Mumbai 400080 India
Review Article Bacterial pathogenomics
Mark J. Pallen1 & Brendan W. Wren2
Abstract
Genomes from all of the crucial bacterial pathogens of humans, plants and animals have now been sequenced, as have genomes from many of the important commensal, symbiotic and environmental microorganisms. Analysis of these sequences has revealed the forces that shape pathogen evolution and has brought to light unexpected aspects of pathogen biology. The finding that horizontal gene transfer and genome decay have key roles in the evolution of bacterial pathogens was particularly surprising. It has also become evident that even the definitions for 'pathogen' and 'virulence factor' need to be re-evaluated.
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NEWS AND VIEWS
Bacterial genomics A plague o' both your hostsNature News and Views (04 Oct 2001)
Beyond comparison?antibiotics from genome data?Nature Biotechnology Research News (01 Dec 2001)
