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Nature 450, 621-622 (29 November 2007) | doi:10.1038/450621a; Published online 28 November 2007
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Cell biology: Pore puzzle
John D. Aitchison1 & Richard W. Wozniak2
Abstract
Where would you start in trying to work out the structure of a macromolecular machine consisting of 456 proteins? Taking a combined experimental and computational approach is one answer.
Consider a 1,000-piece jigsaw puzzle. There are millions of ways in which the pieces might fit together, yet there is only one solution.
- John D. Aitchison is at the Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA.
Email: jaitchison@systemsbiology.org - Richard W. Wozniak is in the Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Email: rick.wozniak@ualberta.ca
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