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Nature 450, 991-1000 (13 December 2007) | doi:10.1038/nature06525; Published online 12 December 2007
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Scientist, Plant Biochemist
- Philip Morris International (PMI)
- Neuchatel, Switzerland
Canada Excellence Research Chair in Biofuels and Biorefining Innovation
- University of British Columbia
- Vancouver, British Columbia Canada
Review Article The biological impact of mass-spectrometry-based proteomics
Benjamin F. Cravatt1,2, Gabriel M. Simon1,2 & John R. Yates III1
Abstract
In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. Using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have been gained. From these studies, it is clear that mass-spectrometry-based proteomics is now a powerful 'hypothesis-generating engine' that, when combined with complementary molecular, cellular and pharmacological techniques, provides a framework for translating large data sets into an understanding of complex biological processes.
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