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Nature 451, 21-22 (3 January 2008) | doi:10.1038/451021a; Published online 2 January 2008

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Down's syndrome: Paradox of a tumour repressor

David W. Threadgill1

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Having three copies of chromosome 21 reduces the incidence of solid tumours in people with Down's syndrome. Studies in mice provide clues to why, and highlight a complex gene–function relationship.

Correlative epidemiological studies are powerful analytical tools that can provide insight into human health and disease. A case in point is the proposition1 that the age-adjusted incidence of solid tumours is lower in individuals with Down's syndrome than in the general population.

  1. David W. Threadgill is in the Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
    Email: dwt@med.unc.edu

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