Table of contents
Volume 452 Number 7183 pp1-126
(this content only available online) indicates content that is available online only
Editorials
No more scavenger hunts p1
The recent media flap over antidepressants highlights the need for data to be transparent — and for a mandatory database of all clinical trials.
doi:10.1038/452001a
Time to connect p1
More than ever, academics in Iran and in nations hostile to it should communicate with each other.
doi:10.1038/452001b
The EPA's tailspin p2
The director of the Environmental Protection Agency is sabotaging both himself and his agency.
doi:10.1038/452002a
News
Crunch time for peer review in lawsuit p6
Ruling imminent on Pfizer's challenge to journal confidentiality.
Meredith Wadman
doi:10.1038/452006a
Bright hopes pervade dark matter p6
Physicists unperturbed as Soudain mine detector draws a blank.
Geoff Brumfiel
doi:10.1038/452006b
Entomologists stifled by Indian bureaucracy p7
'Biopiracy' concerns thwart insect hunters.
K. S. Jayaraman
doi:10.1038/452007a
Save the trees p8
Scientists and policy-makers will meet in Bonn this June to discuss one of the most pressing concerns to come out of December's United Nations climate meeting — how to manage the world's tropical forests. Jeff Tollefson examines some of the proposals.
Jeff Tollefson
doi:10.1038/452008a
Magnets touted as fix for fusion reactor p11
ITER experiment faces up to effects of chaotic eruptions.
Eric Hand
doi:10.1038/452011a
Sidelines p12
Scribbles on the margins of science.
doi:10.1038/452012a
Hobbit was 'a cretin' p12
Fossil may be early example of hypothyroidism.
Rex Dalton
doi:10.1038/news.2008.643
Nobel prizewinner's paper retracted p13
Failure to reproduce results deals blow to work on olfactory networks.
Heidi Ledford
doi:10.1038/452013a
UK scientists keep access to the Gemini telescopes p15
doi:10.1038/452015a
Massachusetts gears up to boost cash for life sciences p15
doi:10.1038/452015b
First of three contested stem-cell patents upheld p15
doi:10.1038/452015c
India to propose regulatory body to curb misconduct p15
doi:10.1038/452015d
US$50 billion agreed for Bush's global AIDS plan p15
doi:10.1038/452015e
Lunar pole is revealed in high resolution p15
doi:10.1038/452015f
Correction p15
doi:10.1038/452015g
Column
The scientist delusion p17
Religious resistance to science is often exaggerated, but fresh problems may lie ahead, says David Goldston.
David Goldston
doi:10.1038/452017a
News Features
Astronomy: Hearing the heavens p18
The cosmos is thought to be awash with gravitational waves to which humanity is, as yet, deaf. Trudy E. Bell reports on LISA, an experiment on an unprecedented scale designed to put that right.
doi:10.1038/452018a
Archaeology: Facing up to the past p22
New York University is trying to establish a world-class archaeological institute — with funds from a philanthropist who has been linked to looted artefacts. Rex Dalton reports.
doi:10.1038/452022a
Oceanography: Red tide rising p24
Algal blooms can make life miserable for coastal dwellers and wreak havoc on marine ecosystems. Mark Schrope reports on Florida's efforts to predict these red tides.
doi:10.1038/452024a
Correspondence
Who stands to lose from double-blind review? p28
Boyan K. Garvalov
doi:10.1038/452028a
Double-blind review: the paw print is a giveaway p28
K. Razi Naqvi
doi:10.1038/452028b
Double-blind review: easy to guess in specialist fields p28
David Lane
doi:10.1038/452028c
Double-blind review: let diversity reign p28
Bob O'Hara
doi:10.1038/452028d
Tibet's seeds must be stored as climate changes p28
W. John Cram, Yang Zhong, Tashi Tersing & Jie Cai
doi:10.1038/452028e
Duplication: stop favouring applicant with longest list p29
Martin Fenner
doi:10.1038/452029a
Duplication spreads the word to a wider audience p29
Daniel David
doi:10.1038/452029b
Duplication and plagiarism increasing among students p29
Brian Derby
doi:10.1038/452029c
Duplication: most cases on database are innocent p29
Paul Brennan
doi:10.1038/452029d
Books and Arts
Physics to Bragg about p30
The first joint biography of the father and son who developed X-ray crystallography.
Jeff Hughes reviews William and Lawrence Bragg, Father and Son: The Most Extraordinary Collaboration in Science by John Jenkin
doi:10.1038/452030a
Climate change for the masses p31
David S. Reay reviews The Hot Topic by Gabrielle Walker & David King
doi:10.1038/452031a
See also: Editor's summary
Hacking: Crafters tinker with technology p32
Krista Zala
doi:10.1038/452032a
Hacking: Home cooking with a twist p32
Jascha Hoffman
doi:10.1038/452032b
Hacking: Toys, bugs and rock 'n' roll p33
Joanne Baker
doi:10.1038/452033a
In Retrospect: The book that began invasion ecology p34
Charles Elton's 50-year-old text founded a field and is now cited more than ever.
Anthony Ricciardi & Hugh J. MacIsaac review The Ecology of Invasions by Animals and Plants by Charles S. Elton
doi:10.1038/452034a
News and Views
Physiology: Keeping it regular with protons p35
Muscle coordination is mostly governed by motor programs built into the nervous system. But one program — the defecation cycle in a worm — has a mechanism that avoids nerves completely and uses protons as signals.
Laura M. Prolo & Miriam B. Goodman
doi:10.1038/452035a
Quantum physics: Tangled memories p37
The latest quantum trick — mapping two entangled photon states onto two separate regions of an atomic cloud, and then retrieving them — could be a fillip for applications, among them quantum cryptography.
Lene Vestergaard Hau
doi:10.1038/452037a
50 & 100 Years Ago p37
doi:10.1038/452037b
Neuroscience: A complex in psychosis p38
The molecular basis of psychoses such as schizophrenia remains largely mysterious. The interaction between two of the brain receptors involved adds to evidence that will help in the search for explanations.
Solomon H. Snyder
doi:10.1038/452038a
See also: Editor's summary
Ageing: Rushed decisions p39
Sadaf Shadan
doi:10.1038/452039a
Palaeontology: Modern life in ancient mats p40
Microbial communities seem to have inhabited tidal sediments 2.9 billion years ago much as they do today — but what organisms were involved, and how they made their living, remain intriguing questions.
Michael M. Tice
doi:10.1038/452040a
Magnetospheric physics: Hiss from the chorus p41
What is the origin of the broadband, low-intensity radio waves thought to control the radiation belts that surround Earth? The latest suggestion sees this 'hiss' emerging from an unsuspected quarter.
Craig J. Rodger & Mark A. Clilverd
doi:10.1038/452041a
See also: Editor's summary
Genomics: Fungal symbiosis unearthed p42
Associations between plant roots and fungi are a feature of many terrestrial ecosystems. The genome sequence of a prominent fungal partner opens new avenues for studying such mycorrhizal interactions.
Dan Cullen
doi:10.1038/452042a
See also: Editor's summary
Solid-state physics: How does your quasicrystal grow? p43
Somewhere between the amorphous glasses and the rigidly regimented periodic crystals lie the quasicrystals: ordered, predictable, yet non-periodic arrangements of atoms. How do these strange structures form?
Paul J. Steinhardt
doi:10.1038/452043a
Brief Communications Arising
Arousal by stimulation of deep-brain nuclei pE1
Hugh Staunton
doi:10.1038/nature06574
First paragraph | Full Text | PDF (85K)
Schiff et al. reply pE1
N. D. Schiff, J. T. Giacino, K. Kalmar, J. D.Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, T. Biondi, J. O'Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins & A. R. Rezai
doi:10.1038/nature06575
First paragraph | Full Text | PDF (85K)
Articles
Cyclical DNA methylation of a transcriptionally active promoter p45
Raphaël Métivier, Rozenn Gallais, Christophe Tiffoche, Christine Le Péron, Renata Z. Jurkowska, Richard P. Carmouche, David Ibberson, Peter Barath, Florence Demay, George Reid, Vladimir Benes, Albert Jeltsch, Frank Gannon & Gilles Salbert
doi:10.1038/nature06544
Abstract | Full Text | PDF (724K) | Supplementary information
See also: Editor's summary
The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data p51
Marc Parisien & François Major
doi:10.1038/nature06684
Abstract | Full Text | PDF (654K) | Supplementary information
See also: Editor's summary
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms p56
Yan Xu, Liang Feng, Philip D. Jeffrey, Yigong Shi & François M. M. Morel
doi:10.1038/nature06636
Abstract | Full Text | PDF (1,149K) | Supplementary information
See also: Editor's summary
Letters
The unexpected origin of plasmaspheric hiss from discrete chorus emissions p62
Jacob Bortnik, Richard M. Thorne & Nigel P. Meredith
doi:10.1038/nature06741
First paragraph | Full Text | PDF (1,690K) | Supplementary information
See also: Editor's summary | News and Views by Rodger & Clilverd
Mapping photonic entanglement into and out of a quantum memory p67
K. S. Choi, H. Deng, J. Laurat & H. J. Kimble
doi:10.1038/nature06670
First paragraph | Full Text | PDF (930K)
See also: News and Views by Hau
Strong dispersive coupling of a high-finesse cavity to a micromechanical membrane p72
J. D. Thompson, B. M. Zwickl, A. M. Jayich, Florian Marquardt, S. M. Girvin & J. G. E. Harris
doi:10.1038/nature06715
First paragraph | Full Text | PDF (1,665K) | Supplementary information
See also: Editor's summary
Multi-membrane hydrogels p76
Sébastien Ladet, Laurent David & Alain Domard
doi:10.1038/nature06619
First paragraph | Full Text | PDF (760K) | Supplementary information
See also: Editor's summary
Near-isothermal conditions in the middle and lower crust induced by melt migration p80
Gabriela V. Depine, Christopher L. Andronicos & Jason Phipps-Morgan
doi:10.1038/nature06689
First paragraph | Full Text | PDF (246K)
High-amplitude fluctuations and alternative dynamical states of midges in Lake Myvatn p84
Anthony R. Ives, Árni Einarsson, Vincent A. A. Jansen & Arnthor Gardarsson
doi:10.1038/nature06610
First paragraph | Full Text | PDF (271K) | Supplementary information
See also: Editor's summary
The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis p88
F. Martin, A. Aerts, D. Ahrén, A. Brun, E. G. J. Danchin, F. Duchaussoy, J. Gibon, A. Kohler, E. Lindquist, V. Pereda, A. Salamov, H. J. Shapiro, J. Wuyts, D. Blaudez, M. Buée, P. Brokstein, B. Canbäck, D. Cohen, P. E. Courty, P. M. Coutinho, C. Delaruelle, J. C. Detter, A. Deveau, S. DiFazio, S. Duplessis, L. Fraissinet-Tachet, E. Lucic, P. Frey-Klett, C. Fourrey, I. Feussner, G. Gay, J. Grimwood, P. J. Hoegger, P. Jain, S. Kilaru, J. Labbé, Y. C. Lin, V. Legué, F. Le Tacon, R. Marmeisse, D. Melayah, B. Montanini, M. Muratet, U. Nehls, H. Niculita-Hirzel, M. P. Oudot-Le Secq, M. Peter, H. Quesneville, B. Rajashekar, M. Reich, N. Rouhier, J. Schmutz, T. Yin, M. Chalot, B. Henrissat, U. Kües, S. Lucas, Y. Van de Peer, G. K. Podila, A. Polle, P. J. Pukkila, P. M. Richardson, P. Rouzé, I. R. Sanders, J. E. Stajich, A. Tunlid, G. Tuskan & I. V. Grigoriev
doi:10.1038/nature06556
First paragraph | Full Text | PDF (402K) | Supplementary information
See also: Editor's summary | News and Views by Cullen
Identification of a serotonin/glutamate receptor complex implicated in psychosis p93
Javier González-Maeso, Rosalind L. Ang, Tony Yuen, Pokman Chan, Noelia V. Weisstaub, Juan F. López-Giménez, Mingming Zhou, Yuuya Okawa, Luis F. Callado, Graeme Milligan, Jay A. Gingrich, Marta Filizola, J. Javier Meana & Stuart C. Sealfon
doi:10.1038/nature06612
First paragraph | Full Text | PDF (2,309K) | Supplementary information
See also: Editor's summary | News and Views by Snyder
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons p98
Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T. Opferman & James N. Ihle
doi:10.1038/nature06604
First paragraph | Full Text | PDF (1,063K) | Supplementary information
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response p103
Daniel A. Muruve, Virginie Pétrilli, Anne K. Zaiss, Lindsay R. White, Sharon A. Clark, P. Joel Ross, Robin J. Parks & Jurg Tschopp
doi:10.1038/nature06664
First paragraph | Full Text | PDF (468K) | Supplementary information
A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing p108
Rouven Bingel-Erlenmeyer,
Rebecca Kohler,
Günter Kramer,
Arzu Sandikci,
Snje
ana Antoli
,
Timm Maier,
Christiane Schaffitzel,
Brigitte Wiedmann,
Bernd Bukau
&
Nenad Ban
doi:10.1038/nature06683
First paragraph | Full Text | PDF (798K) | Supplementary information
Transient cyclical methylation of promoter DNA p112
Sara Kangaspeska, Brenda Stride, Raphaël Métivier, Maria Polycarpou-Schwarz, David Ibberson, Richard Paul Carmouche, Vladimir Benes, Frank Gannon & George Reid
doi:10.1038/nature06640
First paragraph | Full Text | PDF (498K) | Supplementary information
See also: Editor's summary
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G p116
Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris & Hiroshi Matsuo
doi:10.1038/nature06638
PDB code
3D view
First paragraph | Full Text | PDF (692K) | Supplementary information
Corrigendum
Behavioural improvements with thalamic stimulation after severe traumatic brain injury p120
N. D. Schiff, J. T. Giacino, K. Kalmar, J. D. Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, T. Biondi, J. O'Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins & A. R. Rezai
doi:10.1038/nature06818
Retraction
Genetic tracing reveals a stereotyped sensory map in the olfactory cortex p120
Zhihua Zou, Lisa F. Horowitz, Jean-Pierre Montmayeur, Scott Snapper & Linda B. Buck
doi:10.1038/nature06819
Naturejobs
ProspectProspects p121
Are animal-rights attacks affecting career paths?
Gene Russo
doi:10.1038/nj7183-121a
Region
Almost in bloom p122
St Louis wants to become a hub of agricultural biotechnology. All it needs, says Emma Marris, is more start-ups and funds.
Emma Marris
doi:10.1038/nj7183-122a
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0197
Spotlight
Spotlight on Missouri
doi:10.1038/nj0198
Futures
From Alice to everywhere, with love p126
A leap into the unknown.
Chaz Brenchley
doi:10.1038/452126a
