Table of contents
Volume 452 Number 7185 pp253-386
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Editorials
A fresh approach to water p253
The water shortage that threatens humanity will have wide-ranging consequences for agriculture and energy production, requiring significant shifts in the way this precious resource is managed.
doi:10.1038/452253a
See also: Editor's summary
Warning signs p254
Giving drug firms immunity from prosecution over inaccurate labelling would not serve the public.
doi:10.1038/452254a
The EIT farce p254
Universities should target the challenges that a virtual technology powerhouse probably won't meet.
doi:10.1038/452254b
News
222 NIH grants: 22 researchers p258
Grandee grantees are sitting pretty through agency cash crisis.
Eric Hand
doi:10.1038/452258a
The Solar System's first breath p259
NASA's Genesis probe offers clues to the Sun's oxygen.
Eric Hand
doi:10.1038/452259a
Purification with a pinch of salt p260
Climate change, growing populations and political concerns are prompting governments and investors from California to China to take a fresh look at desalination. Quirin Schiermeier wades in.
Quirin Schiermeier
doi:10.1038/452260a
Banking on the future of stem cells p263
Representatives of 21 stem-cell funding agencies from 19 countries — members of the International Stem Cell Forum — met in San Francisco at the end of February to discuss collaborations and how to coordinate cell banks and registries. Among them was Leszek Borysiewicz, head of the UK Medical Research Council (MRC), who spoke to Nature about the effort.
Leszek Borysiewicz
doi:10.1038/452263a
Sidelines p264
Scribbles on the margins of science.
doi:10.1038/452264a
Fly's eye detector spies cosmic-ray cut-off p264
Philip Ball
doi:10.1038/452264b
Snapshot: Zooloddities p265
Anna Petherick
doi:10.1038/452265a
Stem-cell patents confirmed p265
Victory for Wisconsin foundation in landmark ruling.
Erika Check Hayden
doi:10.1038/452265b
Revised ozone standard angers environmentalists p266
doi:10.1038/452266a
Wellcome awards reveal microscopic masterpieces p266
doi:10.1038/452266b
Fresh safety concerns for popular anaemia drugs p266
doi:10.1038/452266c
Saturn flyby is a success despite computer glitch p267
doi:10.1038/452267a
Bonn to play host to dementia research centre p267
doi:10.1038/452267b
Korean institute inquiry prompts two retractions p267
doi:10.1038/452267c
News Features
Water: Water under pressure p269
doi:10.1038/452269a
Water: A long dry summer p270
In parts of the world already facing unreliable food supplies, an uncertain climate adds to the future stress for soils, plants and people. Quirin Schiermeier reports on water strategies for a drier world.
doi:10.1038/452270a
Water: More crop per drop p273
Farmers' yields in the developing world are often limited by unreliable rains. Improving their harvests will require plant breeders, agronomists and geneticists to pull together — but can these experts work out their differences? Emma Marris reports.
doi:10.1038/452273a
Water: Muddy waters p278
India's population is growing, and its water supplies are not keeping pace. Can an ambitious scheme to connect up the country's rivers slake the nation's deepening thirst? Daemon Fairless investigates.
doi:10.1038/452278a
Correspondence
Wildlife disease can put conservation at risk p282
Darrick T. Evensen
doi:10.1038/452282a
Hall and Keynes join Arbor in the citation indexes p282
Daniel C. Postellon
doi:10.1038/452282b
Growth of activism calls for more thoughtful solutions p282
doi:10.1038/452282c
How genetic censorship would harm everyone p282
Marcelino Fuentes
doi:10.1038/452282d
Qualities of a lone author are beneficial to science p282
Kevin Hallock
doi:10.1038/452282e
Commentaries
Improving on haves and have-nots p283
All-or-nothing targets for global access to basic amenities such as drinking water and sanitation are outdated. The time has come, says Jamie Bartram, for a more fluid approach.
doi:10.1038/452283a
See also: Editor's summary
The energy challenge p285
Global energy consumption is expected to grow by 50% by 2030, squeezing already scarce water resources. Mike Hightower and Suzanne A. Pierce recommend ways to integrate water and energy planning.
doi:10.1038/452285a
See also: Editor's summary
Books and Arts
Internet as utility? p287
A sceptic argues that the electricity industry's tale predicts a digital future of diminished privacy.
John Browning reviews The Big Switch: Our New Digital Destiny by Nicholas Carr
doi:10.1038/452287a
See also: Editor's summary
Film: Water policy in the can p288
Emma Marris
doi:10.1038/452288a
See also: Editor's summary
Exhibition: Water works p289
Nick Thomas
doi:10.1038/452289a
Galileo the artist p289
Thomas de Padova reviews Galilei der Künstler. Die Zeichnung, der Mond, die Sonne by Horst Bredekamp
doi:10.1038/452289b
Echoes of time in images of the Antarctic p290
British landscape artist Chris Drury imaginatively interprets radar pictures taken of ancient ice layers underneath the south pole.
Martin Kemp reviews
doi:10.1038/452290a
Essay
Water: Water — an enduring mystery p291
Yet another theory of liquid water structure raises questions about interdisciplinarity, drug design, astrobiology, molecular biology, geochemistry and more.
Philip Ball
doi:10.1038/452291a
See also: Editor's summary
News and Views
Particle physics: Song of the electroweak penguin p293
An unexpected imbalance in how particles containing the heaviest quarks decay might reveal exotic influences — and perhaps help to explain why matter, rather than antimatter, dominates the Universe.
Michael E. Peskin
doi:10.1038/452293a
See also: Editor's summary
Physiology: Brain comes to light p294
To perceive seasons, animals compare changes in day length with the constant cycle of their inner circadian clock. At a molecular level, light signals trigger coordinated gene-expression events in the brain.
Hitoshi Okamura
doi:10.1038/452294a
See also: Editor's summary
50 & 100 Years Ago p295
doi:10.1038/452295a
Extrasolar planets: A whiff of methane p296
Investigations of planets outside our Solar System are becoming ever more sophisticated. The latest development is the discovery of a carbon-containing molecule in the atmosphere of one such extrasolar body.
Adam P. Showman
doi:10.1038/452296a
See also: Editor's summary
Drug discovery: Schistosome treatment p296
Sadaf Shadan
doi:10.1038/452296b
Human behaviour: Punisher pays p297
The tendency of humans to punish perceived free-loaders, even at a cost to themselves, is an evolutionary puzzle: punishers perish, and those who benefit the most are those who have never punished at all.
Manfred Milinski & Bettina Rockenbach
doi:10.1038/452297a
See also: Editor's summary
Quantum physics: Disturbance without the force p298
Charged particles influenced by electromagnetic fields, even when the two never touch? Surely, it can only be quantum physics. But surprisingly, the quantum nature of this particular effect has been disputed.
Akira Tonomura & Franco Nori
doi:10.1038/452298a
Brief Communications Arising
Do abnormal responses show utilitarian bias? pE5
Guy Kahane & Nicholas Shackel
doi:10.1038/nature06785
First paragraph | Full Text | PDF (87K)
Koenigs et al. reply pE5
M. Koenigs, L. Young, R. Adolphs, D. Tranel, F. Cushman, M. Hauser & A. Damasio
doi:10.1038/nature06804
First paragraph | Full Text | PDF (87K)
Review
Science and technology for water purification in the coming decades p301
Mark A. Shannon, Paul W. Bohn, Menachem Elimelech, John G. Georgiadis, Benito J. Mariñas & Anne M. Mayes
doi:10.1038/nature06599
First paragraph | Full Text | PDF (2,116K)
See also: Editor's summary
Articles
Ancient, highly heterogeneous mantle beneath Gakkel ridge, Arctic Ocean p311
Chuan-Zhou Liu, Jonathan E. Snow, Eric Hellebrand, Gerhard Brügmann, Anette von der Handt, Anette Büchl & Albrecht W. Hofmann
doi:10.1038/nature06688
Abstract | Full Text | PDF (709K) | Supplementary information
Thyrotrophin in the pars tuberalis triggers photoperiodic response p317
Nobuhiro Nakao, Hiroko Ono, Takashi Yamamura, Tsubasa Anraku, Tsuyoshi Takagi, Kumiko Higashi, Shinobu Yasuo, Yasuhiro Katou, Saburo Kageyama, Yumiko Uno, Takeya Kasukawa, Masayuki Iigo, Peter J. Sharp, Atsushi Iwasawa, Yutaka Suzuki, Sumio Sugano, Teruyuki Niimi, Makoto Mizutani, Takao Namikawa, Shizufumi Ebihara, Hiroki R. Ueda & Takashi Yoshimura
doi:10.1038/nature06738
Abstract | Full Text | PDF (591K) | Supplementary information
See also: Editor's summary | News and Views by Okamura
Translational control of the innate immune response through IRF-7 p323
Rodney Colina, Mauro Costa-Mattioli, Ryan J. O. Dowling, Maritza Jaramillo, Lee-Hwa Tai, Caroline J. Breitbach, Yvan Martineau, Ola Larsson, Liwei Rong, Yuri V. Svitkin, Andrew P. Makrigiannis, John C. Bell & Nahum Sonenberg
doi:10.1038/nature06730
Abstract | Full Text | PDF (840K) | Supplementary information
See also: Editor's summary
Letters
The presence of methane in the atmosphere of an extrasolar planet p329
Mark R. Swain, Gautam Vasisht & Giovanna Tinetti
doi:10.1038/nature06823
First paragraph | Full Text | PDF (287K) | Supplementary information
See also: Editor's summary | News and Views by Showman
Difference in direct charge-parity violation between charged and neutral B meson decays p332
The Belle Collaboration
doi:10.1038/nature06827
First paragraph | Full Text | PDF (277K) | Supplementary information
See also: Editor's summary | News and Views by Peskin
Super-chondritic Sm/Nd ratios in Mars, the Earth and the Moon p336
Guillaume Caro, Bernard Bourdon, Alex N. Halliday & Ghylaine Quitté
doi:10.1038/nature06760
First paragraph | Full Text | PDF (203K) | Supplementary information
See also: Editor's summary
Biodiversity and biogeography of phages in modern stromatolites and thrombolites p340
Christelle Desnues, Beltran Rodriguez-Brito, Steve Rayhawk, Scott Kelley, Tuong Tran, Matthew Haynes, Hong Liu, Mike Furlan, Linda Wegley, Betty Chau, Yijun Ruan, Dana Hall, Florent E. Angly, Robert A. Edwards, Linlin Li, Rebecca Vega Thurber, R. Pamela Reid, Janet Siefert, Valeria Souza, David L. Valentine, Brandon K. Swan, Mya Breitbart & Forest Rohwer
doi:10.1038/nature06735
First paragraph | Full Text | PDF (293K) | Supplementary information
See also: Editor's summary
Survival variability and population density in fish populations p344
Coilín Minto, Ransom A. Myers & Wade Blanchard
doi:10.1038/nature06605
First paragraph | Full Text | PDF (437K) | Supplementary information
See also: Editor's summary
Winners don't punish p348
Anna Dreber, David G. Rand, Drew Fudenberg & Martin A. Nowak
doi:10.1038/nature06723
First paragraph | Full Text | PDF (256K) | Supplementary information
See also: Editor's summary | News and Views by Milinski & Rockenbach
Identifying natural images from human brain activity p352
Kendrick N. Kay, Thomas Naselaris, Ryan J. Prenger & Jack L. Gallant
doi:10.1038/nature06713
First paragraph | Full Text | PDF (456K) | Supplementary information
See also: Editor's summary
Memory CD4 T cells emerge from effector T-cell progenitors p356
Laurie E. Harrington, Karen M. Janowski, James R. Oliver, Allan J. Zajac & Casey T. Weaver
doi:10.1038/nature06672
First paragraph | Full Text | PDF (1,364K) | Supplementary information
Preserving cell shape under environmental stress p361
Boaz Cook, Robert W. Hardy, William B. McConnaughey & Charles S. Zuker
doi:10.1038/nature06603
First paragraph | Full Text | PDF (516K) | Supplementary information
Control of chromosome stability by the 
-TrCP–REST–Mad2 axis p365
Daniele Guardavaccaro, David Frescas, N. Valerio Dorrello, Angelo Peschiaroli, Asha S. Multani, Timothy Cardozo, Anna Lasorella, Antonio Iavarone, Sandy Chang, Eva Hernando & Michele Pagano
doi:10.1038/nature06641
First paragraph | Full Text | PDF (1,013K) | Supplementary information
SCF
-TRCP controls oncogenic transformation and neural differentiation through REST degradation p370
Thomas F. Westbrook, Guang Hu, Xiaolu L. Ang, Peter Mulligan, Natalya N. Pavlova, Anthony Liang, Yumei Leng, Rene Maehr, Yang Shi, J. Wade Harper & Stephen J. Elledge
doi:10.1038/nature06780
First paragraph | Full Text | PDF (419K) | Supplementary information
X-ray structure of a prokaryotic pentameric ligand-gated ion channel p375
Ricarda J. C. Hilf & Raimund Dutzler
doi:10.1038/nature06717
PDB code
3D view
First paragraph | Full Text | PDF (982K) | Supplementary information
Corrigendum
Structural basis for the function and inhibition of an influenza virus proton channel p380
Amanda L. Stouffer, Rudresh Acharya, David Salom, Anna S. Levine, Luigi Di Costanzo, Cinque S. Soto, Valentina Tereshko, Vikas Nanda, Steven Stayrook & William F. DeGrado
doi:10.1038/nature06845
PDB code
3D view
Naturejobs
ProspectProspects p381
Should the NIH spread its wealth?
Gene Russo
doi:10.1038/nj7185-381a
Special Report
Closing the gaps p382
US researchers are keen to find ways to address health disparities among minorities. Paul Smaglik reports.
Paul Smaglik
doi:10.1038/nj7185-382a
Career View
Mike Tyers, director of the Scottish Universities Life Sciences Alliance, Edinburgh, Scotland p384
Cell-division researcher makes move from Canada to Scotland.
Jill U. Adams
doi:10.1038/nj7185-384a
Sea change in business studies p384
New degree for oceanographers with a business bent.
Virginia Gewin
doi:10.1038/nj7185-384b
Thinner air p384
I'm on a field-research high.
Aliza le Roux
doi:10.1038/nj7185-384c
Highlights
Highlight: Francophone
doi:10.1038/nj0199
Opportunities: The National Institutes of Health
doi:10.1038/nj0200
