Editor's Summary
10 April 2008
Redrawing the blood lines
In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors, and myeloid cells (including granulocytes and macrophages, found in bone marrow and spinal cord) from progenitors committed to the myeloid lineage. Two papers in this issue report evidence that contradicts this. Rather, they find a single type of progenitor in adult thymus with both T and myeloid potential. T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but still produces macrophages and cells with T, NK (natural killer) and dendritic cell potential. These results support a model for haematopoiesis where the progenitor cell at the branch point of T and B cell lineages retains macrophage potential.
News and Views: Immunology: Blood lines redrawn
The generation of blood cells is a complex affair. As the culmination of several years of study by various investigators, the latest research will necessitate revision of textbook accounts of the process.
Thomas Graf
doi:10.1038/452702a
Letter: The earliest thymic progenitors for T cells possess myeloid lineage potential
J. Jeremiah Bell & Avinash Bhandoola
doi:10.1038/nature06840
First paragraph | Full Text | PDF (558K) | Supplementary information
Letter: Adult T-cell progenitors retain myeloid potential
Haruka Wada, Kyoko Masuda, Rumi Satoh, Kiyokazu Kakugawa, Tomokatsu Ikawa, Yoshimoto Katsura & Hiroshi Kawamoto
doi:10.1038/nature06839
First paragraph | Full Text | PDF (898K) | Supplementary information
