Table of contents
Volume 453 Number 7193 pp257-426
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Editorials
The next big climate challenge p257
Governments should work together to build the supercomputers needed for future predictions that can capture the detail required to inform policy.
doi:10.1038/453257a
Stuck in the mud p258
The Environmental Protection Agency must gather data on the toxicity of spreading sewage sludge.
doi:10.1038/453258a
Negative results p258
Retracted papers require a thorough explanation of what went wrong in the experiments.
doi:10.1038/453258b
Research Highlights
Marine ecology: Deep-sea cheetahs p260
doi:10.1038/453260a
Neuroscience: Hearing what and where p260
doi:10.1038/453260b
Palaeoclimate: Methane didn't act alone p260
doi:10.1038/453260c
Geoscience: The dust settles p260
doi:10.1038/453260d
Quantum optics: Open the box p260
doi:10.1038/453260e
Neurobiology: The heart in the head p260
doi:10.1038/453260f
Astronomy: A galaxy far, far away p261
doi:10.1038/453261a
Ecology: Hand-me-down bacteria p261
doi:10.1038/453261b
Ecology: Hot chicks p261
doi:10.1038/453261c
Chemistry: Disulphide dichotomies p261
doi:10.1038/453261d
News
Raking through sludge exposes a stink p262
Environmental Protection Agency scientists accused of fabricating data about health effects of fertilizer.
Jeff Tollefson
doi:10.1038/453262a
German universities bow to public pressure over GM crops p263
Plug is pulled on maize research.
Quirin Schiermeier
doi:10.1038/453263a
Flights of green fancy p264
Air travel shows no sign of losing its allure but its environmental impact is not going to go away. Katharine Sanderson looks at some of the ways that scientists and engineers hope to reduce the carbon wing-print of aircraft.
Katharine Sanderson
doi:10.1038/453264a
Snapshot: Charged clouds p267
Lightning rages over Chilean volcano.
Geoff Brumfiel
doi:10.1038/453267a
A side-splitting tale p267
Sex simulator sheds light on condom ruptures.
Anna Petherick
doi:10.1038/453267b
They say they want a revolution p268
Climate scientists call for major new modelling facility.
Olive Heffernan
doi:10.1038/453268a
Sidelines p269
Scribbles on the margins of science.
doi:10.1038/453269a
Space telescope lands new career in bomb detection p270
doi:10.1038/453270a
Farm bill reduces support for corn ethanol p270
doi:10.1038/453270b
Cosmologist quits Britain over poor physics funding p270
doi:10.1038/453270c
Hefty funds lay foundations for stem-cell facilities p270
doi:10.1038/453270d
Former NASA science director returns to post p270
doi:10.1038/453270e
Forest clearance boosted power of Cyclone Nargis p270
doi:10.1038/453270f
Nature.com wins a webby p270
doi:10.1038/453270g
News Features
Profile: Learning from death p271
Vishva Dixit's study of cellular demise led to the discovery of a new molecular-signalling mechanism — one with implications for inflammation and perhaps much more, reports Melinda Wenner.
doi:10.1038/453271a
Chemistry: Designer Debacle p275
A high-profile scientist, a graduate student and two major retractions. Erika Check Hayden reports on a case that has rocked the chemistry community.
doi:10.1038/453275a
Correspondence
Deforestation: call for justice, not militarization p280
Samuel J. Spiegel
doi:10.1038/453280a
Deforestation: damage from dams adds to emissions p280
André Frainer Barbosa
doi:10.1038/453280b
Hype around nanotubes creates unrealistic hopes p280
Kostas Kostarelos, Alberto Bianco & Maurizio Prato
doi:10.1038/453280c
A case of genetic counselling for Dr Watson p281
Myra I. Roche
doi:10.1038/453281a
The public needs to know social benefits of vaccination p281
Anthony Robbins
doi:10.1038/453281b
Public support never has guaranteed good work p281
Neville W. Goodman
doi:10.1038/453281c
Books and Arts
Big problems, big decisions p282
Sustainable solutions to worldwide crises such as overpopulation and climate change need regulating by global bodies, but whose views should these organizations represent?
Michael Sargent reviews Fatal Misconception: The Struggle to Control World Population by Matthew Connelly and Common Wealth: Economics for a Crowded Planet by Jeffrey D. Sachs
doi:10.1038/453282a
See also: Editor's summary
Enshrining the right to live or die p284
Emily Jackson reviews Understanding Bioethics and the Law: The Promises and Perils of the Brave New World of Biotechnology by Barry R. Schaller and Easeful Death: Is There a Case for Assisted Dying? by Mary Warnock & Elisabeth Macdonald
doi:10.1038/453284a
Charting the water's edge p285
Deborah Jean Warner reviews Coast Lines: How Mapmakers Frame the World and Chart Environmental Change by Mark Monmonier
doi:10.1038/453285a
See also: Editor's summary
Changing perceptions of light p286
Christopher Turner reviews Take Your Time: Olafur Eliasson
doi:10.1038/453286a
Essays
The evolution of music p287
In the second of a nine-part essay series, Josh McDermott explores the origins of the human urge to make and hear music.
Josh McDermott
doi:10.1038/453287a
25 years of HIV p289
Reflecting on how far we have come scientifically since isolating HIV in 1983, Anthony S. Fauci urges a renewed commitment to the far greater challenges ahead, especially that of vaccine development.
Anthony S. Fauci
doi:10.1038/453289a
See also: Editor's summary
News and Views
Palaeoclimate: Windows on the greenhouse p291
Data laboriously extracted from an Antarctic ice core provide an unprecedented view of temperature, and levels of atmospheric carbon dioxide and methane, over the past 800,000 years of Earth's history.
Ed Brook
doi:10.1038/453291a
See also: Editor's summary
Signal transduction: The rhodopsin story continued p292
Determination of the architecture of an invertebrate photoreceptor protein, squid rhodopsin, is a notable event. It illuminates the mechanism of invertebrate vision and a ubiquitous intracellular signalling system.
Gebhard F. X. Schertler
doi:10.1038/453292a
See also: Editor's summary
Quantum information: An integrated light circuit p294
There's a long wish list for a workable quantum computer: a viable system must be fast, compact and stable. The first integrated optical quantum logic circuits are a step in the right direction.
Paul G. Kwiat
doi:10.1038/453294a
Tuberculosis: Deadly combination p295
Many factors affect the severity of tuberculosis in infected individuals. Among these are the genetic make-up of the bacterial strain, that of the host, and the interplay between the two.
Stefan H. E. Kaufmann
doi:10.1038/453295a
Climate change: Attributing cause and effect p296
The climate is changing, and so are aspects of the world's physical and biological systems. It is no easy matter to link cause and effect — the latest attack on the problem brings the power of meta-analysis to bear.
Francis Zwiers & Gabriele Hegerl
doi:10.1038/453296a
See also: Editor's summary
Solid-state physics: Polaritronics in view p297
Polaritons are an odd cross-breed of a particle, half-matter, half-light. They could offer an abundant crop of new and improved optoelectronic devices — a promise already being fulfilled.
Benoît Deveaud-Plédran
doi:10.1038/453297a
See also: Editor's summary
Plant biology: In their neighbour's shadow p298
They can't move away from shade, so plants resort to a molecular solution to find a place in the sun. The action they take is quite radical, and involves a reprogramming of their development.
Ji
í Friml
&
Michael Sauer
doi:10.1038/453298a
50 & 100 years ago p299
doi:10.1038/453299a
Obituary: Edward N. Lorenz (1917–2008) p300
Meteorologist and father of chaos theory.
Edward Ott
doi:10.1038/453300a
Insight: Regenerative medicine -
Insight: Regenerative medicine
Regenerative medicine p301
Natalie DeWitt
doi:10.1038/453301a
Regenerative medicine and human models of human disease p302
Kenneth R. Chien
doi:10.1038/nature07037
Abstract | Full Text | PDF (952K)
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal p306
Leonard I. Zon
doi:10.1038/nature07038
Abstract | Full Text | PDF (735K)
Wound repair and regeneration p314
Geoffrey C. Gurtner, Sabine Werner, Yann Barrandon & Michael T. Longaker
doi:10.1038/nature07039
Abstract | Full Text | PDF (6,567K)
Stem-cell-based therapy and lessons from the heart p322
Robert Passier, Linda W. van Laake & Christine L. Mummery
doi:10.1038/nature07040
Abstract | Full Text | PDF (2,002K)
Tolerance strategies for stem-cell-based therapies p330
Ann P. Chidgey, Daniel Layton, Alan Trounson & Richard L. Boyd
doi:10.1038/nature07041
Abstract | Full Text | PDF (2,101K)
A chemical approach to stem-cell biology and regenerative medicine p338
Yue Xu, Yan Shi & Sheng Ding
doi:10.1038/nature07042
Abstract | Full Text | PDF (1,770K)
Imaging stem-cell-driven regeneration in mammals p345
Timm Schroeder
doi:10.1038/nature07043
Abstract | Full Text | PDF (355K)
Articles
Attributing physical and biological impacts to anthropogenic climate change p353
Cynthia Rosenzweig, David Karoly, Marta Vicarelli, Peter Neofotis, Qigang Wu, Gino Casassa, Annette Menzel, Terry L. Root, Nicole Estrella, Bernard Seguin, Piotr Tryjanowski, Chunzhen Liu, Samuel Rawlins & Anton Imeson
doi:10.1038/nature06937
Abstract | Full Text | PDF (5,935K) | Supplementary information
See also: Editor's summary | News and Views by Zwiers & Hegerl
Nucleosome organization in the Drosophila genome p358
Travis N. Mavrich, Cizhong Jiang, Ilya P. Ioshikhes, Xiaoyong Li, Bryan J. Venters, Sara J. Zanton, Lynn P. Tomsho, Ji Qi, Robert L. Glaser, Stephan C. Schuster, David S. Gilmour, Istvan Albert & B. Franklin Pugh
doi:10.1038/nature06929
Abstract | Full Text | PDF (1,638K) | Supplementary information
See also: Editor's summary
Crystal structure of squid rhodopsin p363
Midori Murakami & Tsutomu Kouyama
doi:10.1038/nature06925
PDB code
3D view
Abstract | Full Text | PDF (1,091K) | Supplementary information
See also: Editor's summary | News and Views by Schertler
Letters
True polar wander on Europa from global-scale small-circle depressions p368
Paul Schenk, Isamu Matsuyama & Francis Nimmo
doi:10.1038/nature06911
First paragraph | Full Text | PDF (2,222K) | Supplementary information
See also: Editor's summary
A GaAs polariton light-emitting diode operating near room temperature p372
S. I. Tsintzos, N. T. Pelekanos, G. Konstantinidis, Z. Hatzopoulos & P. G. Savvidis
doi:10.1038/nature06979
First paragraph | Full Text | PDF (504K)
See also: Editor's summary | News and Views by Deveaud-Plédran
Superconductivity at 43 K in an iron-based layered compound LaO1-xFxFeAs p376
Hiroki Takahashi, Kazumi Igawa, Kazunobu Arii, Yoichi Kamihara, Masahiro Hirano & Hideo Hosono
doi:10.1038/nature06972
First paragraph | Full Text | PDF (729K)
See also: Editor's summary
High-resolution carbon dioxide concentration record 650,000–800,000 years before present p379
Dieter Lüthi, Martine Le Floch, Bernhard Bereiter, Thomas Blunier, Jean-Marc Barnola, Urs Siegenthaler, Dominique Raynaud, Jean Jouzel, Hubertus Fischer, Kenji Kawamura & Thomas F. Stocker
doi:10.1038/nature06949
First paragraph | Full Text | PDF (778K) | Supplementary information
See also: Editor's summary | News and Views by Brook
Orbital and millennial-scale features of atmospheric CH4 over the past 800,000 years p383
Laetitia Loulergue, Adrian Schilt, Renato Spahni, Valérie Masson-Delmotte, Thomas Blunier, Bénédicte Lemieux, Jean-Marc Barnola, Dominique Raynaud, Thomas F. Stocker & Jérôme Chappellaz
doi:10.1038/nature06950
First paragraph | Full Text | PDF (797K) | Supplementary information
See also: Editor's summary | News and Views by Brook
Chemical compass model of avian magnetoreception p387
Kiminori Maeda, Kevin B. Henbest, Filippo Cintolesi, Ilya Kuprov, Christopher T. Rodgers, Paul A. Liddell, Devens Gust, Christiane R. Timmel & P. J. Hore
doi:10.1038/nature06834
First paragraph | Full Text | PDF (543K) | Supplementary information
See also: Editor's summary
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4 p391
Marc Hanikenne, Ina N. Talke, Michael J. Haydon, Christa Lanz, Andrea Nolte, Patrick Motte, Juergen Kroymann, Detlef Weigel & Ute Krämer
doi:10.1038/nature06877
First paragraph | Full Text | PDF (599K) | Supplementary information
See also: Editor's summary
Human metabolic phenotype diversity and its association with diet and blood pressure p396
Elaine Holmes, Ruey Leng Loo, Jeremiah Stamler, Magda Bictash, Ivan K. S. Yap, Queenie Chan, Tim Ebbels, Maria De Iorio, Ian J. Brown, Kirill A. Veselkov, Martha L. Daviglus, Hugo Kesteloot, Hirotsugu Ueshima, Liancheng Zhao, Jeremy K. Nicholson & Paul Elliott
doi:10.1038/nature06882
First paragraph | Full Text | PDF (1,337K) | Supplementary information
See also: Editor's summary
Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning p401
Francesca V. Mariani, Christina P. Ahn & Gail R. Martin
doi:10.1038/nature06876
First paragraph | Full Text | PDF (534K) | Supplementary information
See also: Editor's summary
Free choice activates a decision circuit between frontal and parietal cortex p406
Bijan Pesaran, Matthew J. Nelson & Richard A. Andersen
doi:10.1038/nature06849
First paragraph | Full Text | PDF (649K) | Supplementary information
See also: Editor's summary
Vascular normalization in Rgs5-deficient tumours promotes immune destruction p410
Juliana Hamzah, Manfred Jugold, Fabian Kiessling, Paul Rigby, Mitali Manzur, Hugo H. Marti, Tamer Rabie, Sylvia Kaden, Hermann-Josef Gröne, Günter J. Hämmerling, Bernd Arnold & Ruth Ganss
doi:10.1038/nature06868
First paragraph | Full Text | PDF (565K) | Supplementary information
See also: Editor's summary
3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy p415
Xuekui Yu, Lei Jin & Z. Hong Zhou
doi:10.1038/nature06893
First paragraph | Full Text | PDF (1,269K) | Supplementary information
See also: Editor's summary
Naturejobs
ProspectProspects p421
Aspiring interdisciplinarians should think beyond academia.
Gene Russo
doi:10.1038/nj7193-421a
Postdocs and Students
Assembly work p422
Graduate students can be key links in interdisciplinary science, but training them for this role is a challenge, says Brian Vastag.
Brian Vastag
doi:10.1038/nj7193-422a
Career View
Craig Hogan, director, Center for Particle Astrophysics, Fermi National Accelerator Laboratory and professor of astronomy and astrophysics, University of Chicago, Illinois p424
Incoming director at Fermilab plans fresh focus.
Virginia Gewin
doi:10.1038/nj7193-424a
The postdoc interview p424
Consider asking these questions during your next postdoc interview.
Kryste Ferguson & Ivonne Vidal Pizarro
doi:10.1038/nj7193-424b
Judging me, judging you p424
Conducting a lecture, hoping for a lectureship.
Jon Yearsley
doi:10.1038/nj7193-424c
