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Volume 547 Issue 7664, 27 July 2017

The cover shows the larva of a zebrafish (Danio rerio). In this issue, Florian Engert and his colleagues offer insight into the sensory system that allows fish to detect the flow of the water in which they swim. In a behaviour known as rheotaxis, fish consistently manage to orient and swim against oncoming currents, even when they lack any visual cues. The authors investigated this ability in larval zebrafish, and found that the secret is a series of hair cells — shown in red — known as the lateral line. They propose that these hair cells are used to estimate flow direction by detecting the rotation of local flow fields around the fish body. In the wild, this would enable the fish to navigate in environments that lack visual cues. Cover illustration: Julia Kuhl; zebrafish image: Robert Kasper & Pablo Oteiza

Editorial

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Comment

  • Scientists of all stripes must work with measurement experts so that studies can be compared, urge Martyn Sené, Ian Gilmore and Jan-Theodoor Janssen

    • Martyn Sené
    • Ian Gilmore
    • Jan-Theodoor Janssen
    Comment
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Correspondence

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News & Views

  • Hair-like sensors are suspected to aid fish navigation in complex environments. Laboratory experiments and computational simulations reveal how these sensors can detect water flow to direct the swimming responses of fish. See Letter p.445

    • John O. Dabiri
    News & Views
  • A nanoscale magnetic device that mimics the behaviour of neurons has been used to recognize audio signals. Such a device could be adapted to tackle tasks with greater efficiency than conventional computers. See Letter p.428

    • Frank Hoppensteadt
    News & Views
  • A sophisticated analysis in mice of how inputs to neurons from other neurons are distributed across individual cells of the brain's visual cortex provides information about how mammalian vision is processed. See Letter p.449

    • Tobias Rose
    • Mark Hübener
    News & Views
  • An innovative combination of chemical synthesis, theory and spectroscopy could simplify determination of the structures of naturally occurring, biologically active molecules, which are often leads for drug discovery. See Letter p.436

    • Severin K. Thompson
    • Thomas R. Hoye
    News & Views
  • Polio has almost been eradicated. A field study demonstrates that a combination of focused science and epidemiology, and community-based integrated health approaches, are required to finish the job.

    • Jaime Sepúlveda
    News & Views
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Article

  • In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response.

    • Robert T. Manguso
    • Hans W. Pope
    • W. Nicholas Haining
    Article
  • Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.

    • Azusa Inoue
    • Lan Jiang
    • Yi Zhang
    Article
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Letter

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Technology Feature

  • After tackling the genomes of bacteria and yeast, synthetic biologists are setting their sights on rewriting those of more complex organisms, including humans.

    • Jeffrey M. Perkel

    Collection:

    Technology Feature
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  • Leadership skills need to be nurtured early in a career, say Toddi A. Steelman and Jeffrey J. McDonnell.

    • Toddi A. Steelman
    • Jeffrey J. McDonnell

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Futures

  • A global success?

    • Jack McDevitt
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