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As emerged vividly at this year's international AIDS conference, prospects have never been so bright for new therapies. But some tales are spreading that are fictitious.
Cell proliferation in many tissues is regulated by p27 protein, which binds and inhibits cyclin-dependent kinases. A crystal structure reveals the remarkable mechanisms by which p27 paralyses these enzymes, arresting the cell cycle.
This issue covers the reagents and equipment necessary for cellular and molecular imaging and detection, including a luminometer, a phosphor imaging system, reagents to detect intracellular cytokines and alternatives to radiolabelling.