Meeting program

The Genomics of Common Diseases 2008


Saturday, September 6
1:00 pm - 3:15 pm Registration — Broad Museum Lobby
3:15 pm - 3:30 pm Welcome and Introductions
David Altshuler, Broad Institute of MIT and Harvard, Tim Aitman, Imperial College London, UK and Kyle Vogan, Nature Genetics, USA
3:30 pm - 5:45 pm Common diseases 1
3:30 Common variants influencing Type 2 diabetes, body mass index and glucose
Mark McCarthy
University of Oxford, United Kingdom
4:00 Genome-wide association studies of breast and prostate cancer
David J. Hunter
Harvard School of Public Health, USA
4:30 Coffee Break
5:00 Dissecting the genetic architecture of Type 1 diabetes via genome-wide association of 16,783 individuals
Jeffrey C. Barrett
University of Cambridge, United Kindgom
5:15Host responses to HIV-1: the role of rare and common variants
David B. Goldstein
Duke University, USA
5:45 pm - 6:45 pm Keynote lecture 1
Chair: Richard Gibbs, Baylor College of Medicine, USA
Rare mutations in complex diseases: not so rare and not so complex
Helen H.Hobbs
University of Texas Southwestern, USA
6:45 pm - 8:15 pm Welcome Reception - Broad Institute
Sunday, September 7
8:00 am - 8:30 am Breakfast
8:30 am - 10:30 am Population genetics, statistics and evolution
8:30 High-throughput genotyping and population genomics of P. falciparum malaria
Pardis C. Sabeti
Broad Institute of MIT and Harvard, USA
9:00 Power of deep all-exon resequencing for discovery of human trait genes
Shamil Sunyaev
Brigham & Women's Hospital and Harvard Medical School, USA
9:15 Co-adapted alleles and the evolution of complex traits
Gary A. Churchill
The Jackson Laboratory, USA
9:45 Genome-wide association studies of 13 metabolic traits on the Pacific Island of Kosrae suggest shared genetic architecture across populations
Jennifer K. Lowe
Broad Institute of MIT and Harvard, USA
10:00Translational research opportunities afforded by genome wide association study results
Eric Boerwinkle
University of Texas Houston, USA
10:30 am - 11:00 am Coffee Break
11:00 am - 1:00 pm Technologies
11:00 Using new DNA sequencing technologies to tackle fundamental problems in human genetics
Richard Gibbs
Baylor College of Medicine, USA
11:30 Single molecule and single cell DNA sequencing
Steve Quake
Stanford University, USA
12:00 Capturing and sequencing the protein coding genome
Jay Shendure
University of Washington, USA
12:30 Nature's powerful DNA sequencing engine: single- molecule real-time sequencing-by-synthesis
Stephen W. Turner
Pacific Biosciences, USA
1:00 pm - 2:00 pm Lunch
2:00 pm - 3:15 pm Poster session A — Broad Institute Lobby and Mezzanine
2:45 pm - 3:15 pm Coffee Break
3:15 pm - 5:30 pm Gene expression
3:15 Reconstructing the circuits of disease: from molecular states to physiological states
Eric E. Schadt
Rosetta Inpharmatics/Merck & Co, USA
3:45 Population genetics and genomics of human gene expression
Emmanouil T. Dermitzakis
Wellcome Trust Sanger Institute, United Kingdom
4:15 Gene expression levels in African Americans vary with both cis- and trans-genetic ancestry
Alkes L. Price
Harvard School of Public Health, USA
4:30 Sequencing the mammalian epigenome
Bradley E. Bernstein
Massachusetts General Hospital and Harvard Medical School, USA
5:00 Global analysis of cis-regulatory elements in the human genome
Bing Ren
University of California San Diego, USA
7:00 pm - 10:30 pm Conference Dinner at Museum of Science, Boston
Monday, September 8
8:00 am - 8:30 am Breakfast
8:30 am - 10:30 am Germline and somatic variants
8:30 Systematic sequencing of the coding X chromosome to identify germline disease-predisposing variants in mental retardation
Michael Stratton
Wellcome Trust Sanger Institute, United Kingdom
9:00 Genomic analyses of human cancer
Victor Velculecsu
Johns Hopkins University, USA
9:30 Sequencing acute myeloid leukemia genomes with 'next generation' technologies
Timothy J. Ley
Washington University Medical School, USA
10:00 Identifying human sequence variants from whole genome short read sequencing data
Richard Durbin
Wellcome Trust Sanger Institute, United Kingdom
10:30 am - 11:00 am Coffee Break
11:00 am - 12:45 pm Cell and animal models
11:00 Large-scale identification of tissue-specific enhancers in vivo
Len Pennacchio
Lawrence Berkeley National Laboratory, USA
11:30 Unraveling the mysteries at 8q24
Gerhard Coetzee
University of Southern California Cancer Center, USA
11:45 Deciphering and reconstructing the embryonic stem cell transcriptional regulatory network
Huck-Hui Ng
Genome Institute of Singapore, Singapore
12:15 Genome approaches to dissecting cardiovascular and metabolic risk factors in rats
Norbert Hübner
Max-Delbrueck-Center for Molecular Medicine, Germany
12:45 pm - 2:00 pm Lunch
2:00 pm - 3:30 pm Poster session B — Broad Institute Lobby and Mezzanine
3:30 pm - 4:00 pm Coffee Break
4:00 pm - 5:00 pm Keynote lecture 2
Chair: David Altshuler, Broad Institute of MIT and Harvard
Sequence variants associating with the risk of common diseases
Kári Stefánsson
deCODE Genetics, Iceland
5:00 pm - 6:30 pm Personal genomics and society: discussion
Moderator: Teri Manolio
National Human Genome Research Institute, USA
Panel:
George Church, Harvard University, USA
David Valle, Johns Hopkins University, USA
Sharon Terry, Genetic Alliance, USA
6:30 pm - 8:00 pm Reception — Broad Institute
Tuesday, September 9
8:00 am - 8:30 am Breakfast
8:30 am - 10:30 am Structural variation
8:30 Rare and recurrent genome structural variation: a cause of common disease?
Evan E. Eichler
University of Washington, USA
9:00 Selection and instability shape tumor genomes
Donna G. Albertson
University of California San Francisco, USA
9:30 Structural variation: population genetics and association studies
Matthew Hurles
Wellcome Trust Sanger Institute, United Kingdom
10:00 Contribution of copy number variation to common disease
Steven A. McCarroll
Broad Institute of MIT and Harvard, USA
10:30 am - 11:00 am Coffee Break
11:00 pm - 12:00 pm Keynote lecture 3
Chair: Tim Aitman, Imperial College London, UK
Genome-wide association studies and their follow-up
Peter Donnelly
Wellcome Trust Centre for Human Genetics, United Kingdom
12:00 pm - 1:00 pm Lunch
1:00 pm - 3:15 pm Common diseases 2
1:00 Crohn's disease: moving beyond successful genome-wide association studies
Mark J. Daly
Harvard Medical School, USA
1:30 The genetics of inflammatory bowel disease
Judy Cho
Yale University, USA
2:00 Genome-wide association studies of bipolar disorder and schizophrenia
Pamela Sklar
Massachusetts General Hospital, USA
2:30 A 32,000 person genome-wide association study identifies many new loci influencing adult height, but finds no evidence for gender specific effects
Michael Weedon
Peninsula College of Medicine and Dentistry, United Kingdom
2:45 Genome-wide association studies for breast cancer
Douglas F.Easton
University of Cambridge, United Kingdom
3:15 pm Closing remarks
3:30 pm Close of conference

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