Cho et al. reconstruct the regulatory and functional architecture of the E. coli genome by integrating data from several high-throughput measurements. The detailed map will allow developing more detailed models of the networks controlling transcription and translation in E. coli.

As the first commercial ventures are formed around induced pluripotent stem cells, who will have freedom to operate commercially remains an unknown.

In many sequencing applications, it is sufficient to sequence selected portions of a genome rather than the complete genome. Tewhey et al. describe an approach for massively parallel genome targeting that relies on PCR in microdroplets generated by a microfluidic device.

With a flood of cancer genome sequences expected soon, distinguishing 'driver' from 'passenger' mutations will be an important task. Wang et al. describe a bioinformatic method for identifying cancer-associated fusions and apply it to discover a recurrent rearrangement in lung cancer.