Nature Biotechnology22, 1249 - 1252 (2004)
Published online: 6 October 2004; | doi:10.1038/nbt1020
The evolution of molecular biology into systems biology
Hans V Westerhoff1
& Bernhard O Palsson2
1
Departments of Molecular Cell Physiology and Mathematical Biochemistry, BioCentrum Amsterdam, De Boelelaan 1085, NL-108, HV Amsterdam, the Netherlands.
2
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0412, USA.
Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics revolution has catapulted molecular biology into the realm of systems biology. In unicellular organisms and well-defined cell lines of higher organisms, systems approaches are making definitive strides toward scientific understanding and biotechnological applications. We argue here that two distinct lines of inquiry in molecular biology have converged to form contemporary systems biology.
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