All systems go! - p1179

doi:10.1038/ncb1106-1179

Full Text - All systems go! | PDF (102 KB) - All systems go!

Focus on Systems biology: a user's guide

Linking publication, gene and protein data - pp1183 - 1189

Paul Kersey & Rolf Apweiler

doi:10.1038/ncb1495

Abstract - | Full Text - Linking publication, gene and protein data | PDF (773 KB) - Linking publication, gene and protein data | Supplementary information

Focus on Systems biology: a user's guide

Modelling data across labs, genomes, space and time - pp1190 - 1194

Jason R. Swedlow, Suzanna E. Lewis & Ilya G. Goldberg

doi:10.1038/ncb1496

Abstract - | Full Text - Modelling data across labs, genomes, space and time | PDF (183 KB) - Modelling data across labs, genomes, space and time

Focus on Systems biology: a user's guide

Physicochemical modelling of cell signalling pathways - pp1195 - 1203

Bree B. Aldridge, John M. Burke, Douglas A. Lauffenburger & Peter K. Sorger

doi:10.1038/ncb1497

Abstract - | Full Text - Physicochemical modelling of cell signalling pathways | PDF (565 KB) - Physicochemical modelling of cell signalling pathways

Focus on Systems biology: a user's guide

Modelling microtubule patterns - pp1204 - 1211

Eric Karsenti, François Nédélec & Thomas Surrey

doi:10.1038/ncb1498

Abstract - | Full Text - Modelling microtubule patterns | PDF (351 KB) - Modelling microtubule patterns

Biofluorescence: the making of a new technology - p1212

Jennifer Lippincott-Schwartz reviews Aglow in the dark: The revolutionary science of biofluorescence by Vincent Pieribone & David Gruber

doi:10.1038/ncb1106-1212

Full Text - Biofluorescence: the making of a new technology | PDF (117 KB) - Biofluorescence: the making of a new technology

ROS as a tumour suppressor? - pp1213 - 1215

Matthew R. Ramsey & Norman E. Sharpless

doi:10.1038/ncb1106-1213

Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.

Full Text - ROS as a tumour suppressor? | PDF (153 KB) - ROS as a tumour suppressor?

Ahead of the curve: mitochondrial fusion and phospholipase D - pp1215 - 1217

Robert E. Jensen & Hiromi Sesaki

doi:10.1038/ncb1106-1215

A new study has identified a novel phospholipase D (PLD) that is located in the mitochondrial outer membrane and is required for organelle fusion. As PLD-catalysed production of fusogenic lipids is critical for many examples of membrane fusion (such as those mediated by SNAREs), this startling finding raises the possibility that mitochondria use a mechanism common to other cellular fusion events.

Full Text - Ahead of the curve: mitochondrial fusion and phospholipase D | PDF (212 KB) - Ahead of the curve: mitochondrial fusion and phospholipase D

PERing in their sleep - p1217

Sowmya Swaminathan

doi:10.1038/ncb1106-1217

Full Text - PERing in their sleep | PDF (221 KB) - PERing in their sleep

Working out coupled monoubiquitination - pp1218 - 1219

Kaisa Haglund & Harald Stenmark

doi:10.1038/ncb1106-1218

Ubiquitin receptors that bind ubiquitinated proteins through ubiquitin-binding domains have key roles in various cellular processes. These receptors are often themselves monoubiquitinated, referred to as coupled monoubiquitination. Now, coupled monoubiquitination has been shown to involve monoubiquitination of a ubiquitin ligase and its subsequent interaction with a ubiquitin receptor.

Full Text - Working out coupled monoubiquitination | PDF (143 KB) - Working out coupled monoubiquitination

SePARating polarity and proliferation in ErbB2 oncogenesis - pp1220 - 1222

Stephanie J. Walker & Joan S. Brugge

doi:10.1038/ncb1106-1220

Loss of tissue organization, including disruption of epithelial polarity, is a feature of many carcinomas. Activation of the oncogenic receptor tyrosine kinase, ErbB2, induces alterations in epithelial architecture, but the mechanisms underlying this effect are poorly understood. New data suggests that the polarity proteins, Par6 and atypical PKC, may affect epithelial polarity and cell survival through interactions with an ErbB2 receptor complex.

Full Text - SePARating polarity and proliferation in ErbB2 oncogenesis | PDF (516 KB) - SePARating polarity and proliferation in ErbB2 oncogenesis

VEGF controls endothelial-cell permeability by promoting the -arrestin-dependent endocytosis of VE-cadherin - pp1223 - 1234

Julie Gavard & J. Silvio Gutkind

doi:10.1038/ncb1486

Abstract - | Full Text - VEGF controls endothelial-cell permeability by promoting the -arrestin-dependent endocytosis of VE-cadherin | PDF (2,404 KB) - VEGF controls endothelial-cell permeability by promoting the -arrestin-dependent endocytosis of VE-cadherin | Supplementary information

Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control - pp1235 - 1245

Victoria Aranda, Teresa Haire, Marissa E. Nolan, Joseph P. Calarco, Avi Z. Rosenberg, James P. Fawcett, Tony Pawson & Senthil K. Muthuswamy

doi:10.1038/ncb1485

Abstract - | Full Text - Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control | PDF (1,862 KB) - Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control | Supplementary information

See also: News and Views by Walker & Brugge

Molecular mechanisms of coupled monoubiquitination - pp1246 - 1254

Tanja Woelk, Barbara Oldrini, Elena Maspero, Stefano Confalonieri, Elena Cavallaro, Pier Paolo Di Fiore & Simona Polo

doi:10.1038/ncb1484

First Paragraph - | Full Text - Molecular mechanisms of coupled monoubiquitination | PDF (3,703 KB) - Molecular mechanisms of coupled monoubiquitination | Supplementary information

See also: News and Views by Haglund & Stenmark

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis - pp1255 - 1262

Seok-Yong Choi, Ping Huang, Gary M. Jenkins, David C. Chan, Juergen Schiller & Michael A. Frohman

doi:10.1038/ncb1487

First Paragraph - | Full Text - A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis | PDF (2,388 KB) - A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis | Supplementary information

See also: News and Views by Jensen & Sesaki

TRAPPII subunits are required for the specificity switch of a Ypt–Rab GEF - pp1263 - 1269

Nadya Morozova, Yongheng Liang, Andrei A. Tokarev, Shu H. Chen, Randal Cox, Jelena Andrejic, Zhanna Lipatova, Vicki A. Sciorra, Scott D. Emr & Nava Segev

doi:10.1038/ncb1489

First Paragraph - | Full Text - TRAPPII subunits are required for the specificity switch of a Ypt–Rab GEF | PDF (4,880 KB) - TRAPPII subunits are required for the specificity switch of a Ypt–Rab GEF | Supplementary information

CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse - pp1270 - 1276

Regina Tavano, Rita Lucia Contento, Sonia Jimenez Baranda, Marzia Soligo, Loretta Tuosto, Santos Manes & Antonella Viola

doi:10.1038/ncb1492

First Paragraph - | Full Text - CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse | PDF (1,264 KB) - CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse | Supplementary information

CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation - pp1277 - 1283

Leigh Ann Higa, Min Wu, Tao Ye, Ryuji Kobayashi, Hong Sun & Hui Zhang

doi:10.1038/ncb1490

First Paragraph - | Full Text - CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation | PDF (622 KB) - CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation | Supplementary information

Control of Rad52 recombination activity by double-strand break-induced SUMO modification - pp1284 - 1290

Meik Sacher, Boris Pfander, Carsten Hoege & Stefan Jentsch

doi:10.1038/ncb1488

First Paragraph - | Full Text - Control of Rad52 recombination activity by double-strand break-induced SUMO modification | PDF (2,561 KB) - Control of Rad52 recombination activity by double-strand break-induced SUMO modification | Supplementary information

Mitogenic signalling and the p16^INK4a–Rb pathway cooperate to enforce irreversible cellular senescence - pp1291 - 1297

Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Shin-ichi Iida, Hidetoshi Tahara, Keiko Nakayama, Keiichi I. Nakayama, Toshinori Ide, Hideyuki Saya & Eiji Hara

doi:10.1038/ncb1491

First Paragraph - | Full Text - Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence | PDF (2,043 KB) - Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence | Supplementary information

See also: News and Views by Ramsey & Sharpless

Input from Ras is required for maximal PI(3)K signalling in Drosophila - pp1298 - 1302

Mariam H. Orme, Saif Alrubaie, Gemma L. Bradley, Cherryl D. Walker & Sally J. Leevers

doi:10.1038/ncb1493

First Paragraph - | Full Text - Input from Ras is required for maximal PI(3)K signalling in Drosophila | PDF (823 KB) - Input from Ras is required for maximal PI(3)K signalling in Drosophila | Supplementary information

Gs and the Ras binding domain of p110 are both important regulators of PI3K signalling in neutrophils - pp1303 - 1309

Sabine Suire, Alison M. Condliffe, G. John Ferguson, Chris D. Ellson, Hervé Guillou, Keith Davidson, Heidi Welch, John Coadwell, Martin Turner, Edwin R. Chilvers, Phillip T. Hawkins & Len Stephens

doi:10.1038/ncb1494

First Paragraph - | Full Text - Gs and the Ras binding domain of p110 are both important regulators of PI3K signalling in neutrophils | PDF (998 KB) - Gs and the Ras binding domain of p110 are both important regulators of PI3K signalling in neutrophils | Supplementary information

Corrigendum - p1309

doi:10.1038/ncb1106-1309

Full Text - Corrigendum | PDF (102 KB) - Corrigendum