Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis
Jeremy T. Smyth, John G. Petranka, Rebecca R. Boyles, Wayne I. DeHaven, Miwako Fukushima, Katina L. Johnson, Jason G. Williams & James W. Putney Jr
Published online: 01 November 2009 | doi:10.1038/ncb1995
During mitosis, store-operated Ca2+ entry (SOCE) is suppressed. Translocation of the ER Ca2+ sensor STIM1 to the plasma membrane is critical to SOCE activation, but in mitotic cells STIM1 is phosphorylated and fails to rearrange into near-plasma membrane puncta. Mutation of mitosis-specific phosphorylation sites rescues mitotic SOCE.
First Paragraph - Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis | Full Text - Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis | PDF (3,075 KB) - Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis | Supplementary information
Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling
Connie W. Woo, Dongying Cui, Jerry Arellano, Bernhard Dorweiler, Heather Harding, Katherine A. Fitzgerald, David Ron & Ira Tabas
Published online: 25 October 2009 | doi:10.1038/ncb1996
Under prolonged ER stress, expression of the unfolded protein response effector CHOP becomes cytotoxic. Toll-like receptor engagement activates TRIF signalling to inhibit the translational activation of the UPR effector ATF4 and thus suppresses CHOP-associated cell death and organ dysfunction in mice.
First Paragraph - Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling | Full Text - Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling | PDF (2,347 KB) - Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Cell Biology advance online publication, day month year (doi:10.1038/ncbXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Cell Biology volume, page (year); advance online publication, (doi:10.1038/ncbXXXXX)".
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