Nature Chemical Biology - Current Issue : November 2009 - Vol 5 No 11
Latest Highlights
Current issue
This special issue contains a collection of articles that discuss our current understanding of protein dynamics and the methods used to study the dynamics of individual proteins and their interactions with the larger biological systems where they function.
Primer
PRIMER: Kinase inhibitors
Kinase inhibitorsFree!
Kinases are key regulators of cellular signaling and among the most important classes of drug targets. In this Primer, we highlight the different mechanisms employed by kinase inhibitors.
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Advance online publication
Culture conditions
Brief Communication by YangBacteria interact with their environment and other species in part by excreting chemical compounds. New research uses thin layer agar culturing of bacterial colonies combined with imaging mass spectrometry to provide spatial and temporal resolution to these chemical interchanges.
Advance online publication
Metalloenzyme by design
Brief Communication by FaiellaDe novo design of enzymes remains a significant challenge. Introducing two glycines in a helix near a di-iron site and compensating for the substantial loss of protein stability by optimizing a loop sequence successfully converted an iron binding protein to a phenol oxidase.
Advance online publication
Mixing up metabolism
Article by RuizCoenzyme A biosynthesis requires phosphopantethenoylcysteine decarboxylase activity, a function that normally resides in a homotrimeric protein. New research shows that yeast use a heteromeric assembly in which different proteins contribute necessary active site residues.
Advance online publication
Predator and prey on the move
Article by SongA connection between long-range chemical signals and short-range motile events in modulating biodiversity is evident as motility affected biodiversity differently depending on the spatiotemporal locations of the predator and prey in an engineered model of a microbial ecosystem.
Advance online publication
Resisting change
Article by RobertsThe spectrum of infectious structures of the yeast prion protein show differing sensitivities to disruption by the catechin EGCG. Synergistic combinations of discrete anti-amyloid compounds are needed to alleviate multiple structures underlying distinct disease states.
Lipidomics Gateway
Introducing the Lipidomics Gateway. Explore the properties and roles of lipids across biology, and discover powerful new techniques for their production and study. All for free!
