Supplementary information
From the following article
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sovan Sarkar, Ethan O Perlstein, Sara Imarisio, Sandra Pineau, Axelle Cordenier, Rebecca L Maglathlin, John A Webster, Timothy A Lewis, Cahir J O'Kane, Stuart L Schreiber & David C Rubinsztein
Nature Chemical Biology 3, 331 - 338 (2007) Published online: 7 May 2007
doi:10.1038/nchembio883
Supplementary Fig. 1
Results of a small-molecule screen for suppressors (SMIRs) and enhancers (SMERs) of the cytostatic effects of rapamycin in yeast, and characterization, potency and selectivity of the identified SMIRs and SMERs.
Supplementary Fig. 2
Screen for the autophagy-inhibitory SMIRs and the autophagy-inducing SMERs in mammalian cell line.
Supplementary Fig. 3
The effect of SMERs 10, 18 and 28 on mTOR activity, Beclin-1/Atg6, Atg5, Atg7, Atg12, Atg5-Atg12 conjugation and proteasome activity.
Supplementary Methods
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