Volume 20
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No. 5 May 2024
A checkpoint for insulin secretionA chemical screen reveals that inhibitors of CHEK2, a checkpoint kinase, can enhance glucose-stimulated insulin secretion in human primary islets and animal models. The cover shows a confocal microscopy image of a human islet immunostained with antibodies against insulin (green), Ki67 (red) and DAPI (blue).
See Chong et al.
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No. 4 April 2024
Putting the brakes on dyneinCytoplasmic dynein is a motor complex that transports intracellular cargos toward the minus end of microtubules. The image depicts Lis1 binding to the dynein motor domain to facilitate the assembly of active dynein complexes, leading to a slower transport speed.
See Kusakci et al.
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No. 3 March 2024
Concentrated by condensatesSmall molecules can concentrate in diverse cellular compartments. The image, captured by two-photon microscopy, shows the accumulation of tryptanthrin, a quinazoline indole alkaloid and active ingredient in medicinal herbs, within biomolecular condensates and cytoplasmic organelles.
See Kilgore et al.
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No. 2 February 2024
Peaks and valleys of GPCR signalingThe spatial organization of GPCRs is closely associated with their signaling responses and cellular function. Kockelkoren et al. reveal that the spatial organization is energetic coupling of receptors to the curvature of the plasma membrane. The image depicts the landscape of GPCR distribution at the plasma membrane of living cells.
See Kockelkoren et al.
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No. 1 January 2024
Living with lipid mimicsGenetic code expansion (GCE) techniques are valuable for studying post-translational modifications by incorporating modified non-canonical amino acids into specific sites within target proteins. The image depicts lipidated proteins produced via GCE anchored to the membrane.
See Ding et al.