Advance online publication
The latest papers brought to you ahead of print publication by Nature Clinical Practice. Advance online publication papers are listed below.
About advance online publication
Clinical Advance
Atrial fibrillation and congestive heart failure: should we aim to control the heart's rate or its rhythm?
Published online:
28 October 2008
doi:10.1038/ncpcardio1377 |
Full Text | PDF (154K)
Are pediatricians responsible for prevention of adult cardiovascular disease?
Published online:
28 October 2008
doi:10.1038/ncpcardio1389 |
Full Text | PDF (165K)
Translation of evidence-based guidelines in preventive cardiology: the EUROACTION program
Published online:
21 October 2008
doi:10.1038/ncpcardio1386 |
Full Text | PDF (165K)
Assessment of microvascular injury after acute myocardial infarction: importance of the area at risk
Published online:
14 October 2008
doi:10.1038/ncpcardio1373 |
Full Text | PDF (168K)
Home blood pressure monitoring: a new standard method for monitoring hypertension control in treated patients
Published online:
14 October 2008
doi:10.1038/ncpcardio1374 |
Full Text | PDF (164K)
Implantable cardioverter-defibrillator lead failure: how weak is the link?
Published online:
07 October 2008
doi:10.1038/ncpcardio1367 |
Full Text | PDF (164K)
Early repolarization and sudden cardiac arrest: theme or variation on a theme?
Published online:
07 October 2008
doi:10.1038/ncpcardio1354 |
Full Text | PDF (174K)
Is an invasive interventional strategy of value in non-ST-elevation acute coronary syndromes?
Published online:
07 October 2008
doi:10.1038/ncpcardio1368 |
Full Text | PDF (160K)
Viewpoints
Hypertrophic obstructive cardiomyopathy and sleep-disordered breathing: an unfavorable combination
In this thought-provoking Viewpoint and accompanying clinical vignettes, Sengupta and colleagues posit that clinicians should be aware of obstructive sleep apnea in patients with hypertrophic obstructive cardiomyopathy. They hypothesize that this sleep disorder could be the reason cardiomyopathy symptoms remain despite therapy and could also contribute to a raised gradient seen in some patients.
Published online:
18 November 2008
doi:10.1038/ncpcardio1401 |
Full Text | PDF (172K)
Myocardial protection: is primary PCI enough?
Published online:
14 October 2008
doi:10.1038/ncpcardio1371 |
Full Text | PDF (173K)
The relevance of prosthesis–patient mismatch after aortic valve replacement
Patient-prosthesis mismatch (PPM) is common after aortic valve replacement and has been shown to be associated with poor hemodynamic and symptomatic status, a high rate of cardiac events, and increased mortality. In this article, Philippe Pibarot and Jean G. Dumesnil highlight the importance of defining and recognizing PPM and its clinical impact. They also assert that, because PPM is a predictable and modifiable risk factor, it is vital to identify susceptible patients and to apply preventive strategies to avoid PPM or reduce its severity.
Published online:
07 October 2008
doi:10.1038/ncpcardio1366 |
Full Text | PDF (168K)
Reviews
Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future
Aspirin can effectively prevent arterial thrombosis; however, its efficacy is limited as it inhibits the synthesis of only one platelet agonist (thromboxane A2). Here Raju and colleagues review agents that target ADP-mediated platelet activation. They examine controversies and unresolved issues associated with clopidogrel—the optimum loading dose, duration of treatment and incomplete platelet inhibition—and the new ADP-receptor antagonists prasugrel, AZD6140 and cangrelor, and explore their potential relative to each other and to clopidogrel.
Published online:
28 October 2008
doi:10.1038/ncpcardio1372 |
Full Text | PDF (546K)
Structural remodeling in atrial fibrillation
Atrial fibrillation is characterized by structural remodeling of the atrial myocardium—a slow process that comprises morphological changes that affect atrial myocardial architecture and atrial ultrastructure. Here Corradi et al. examine the morphological changes that characterize the fibrillating atrial myocardium at histological and ultrastructural levels, and explore how the pathogenetic mechanisms involved in AF could lead to new treatments.
Published online:
14 October 2008
doi:10.1038/ncpcardio1370 |
Full Text | PDF (751K)
Vascular complications of selected cancer therapies
Vascular complications following cancer treatment are relatively common, particularly in patients with advanced stages of cancer. In this Review, Dr Daher and Dr Yeh describe the vascular complications of treatment with 5-fluorouracil, bevacizumab, and several new tyrosine kinase inhibitors, with special emphasis on thrombotic complications and hypertension.
Published online:
14 October 2008
doi:10.1038/ncpcardio1375 |
Full Text | PDF (397K)
Case Study
Acute hemodynamic changes in percutaneous transluminal septal coil embolization for hypertrophic obstructive cardiomyopathy
Ramcharitar and colleagues present an interesting case of a patient with drug-refractory hypertrophic obstructive cardiomyopathy and NYHA class II–III heart failure who was treated with septal coil embolization. This article demonstrates, for the first time, the acute changes in hemodynamics that occur following septal coil embolization, and shows that this treatment is a viable alternative to percutaneous coronary intervention.
Published online:
07 October 2008
doi:10.1038/ncpcardio1355 |
Full Text | PDF (412K)
Clinical research
Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study
Combined intracoronary and intramyocardial administration might improve outcomes for bone-marrow-derived stem cell therapy for acute myocardial infarction. In this paper patients with left ventricular ejection fraction less than 45% after acute myocardial infarction were randomly assigned stem cell delivery via intramyocardial injection and intracoronary infusion 3–6 weeks or 3–4 months after AMI. Their data shows that combined cardiac stem cell delivery induces a moderate but significant improvement in myocardial infarct size and left ventricular function.
Published online:
11 November 2008
doi:10.1038/ncpcardio1388 |
Full Text | PDF (720K)
Circulating white blood cells and platelets amplify oxidative stress in heart failure
Mitochondria of circulating white blood cells (WBC) and platelets sense oxidative stress during capillary passage and react by producing reactive oxygen species (ROS). Evidence indicates that congestive heart failure (CHF) is associated with oxidative stress; however, the role of WBC and platelets as mediators in CHF has not been investigated. In this paper the authors conducted an observational study to investigate the degree of oxidation in WBC and platelets in patients with CHF and healthy volunteers. Their data shows that in CHF, the proportion of WBC and platelets that are ROS positive is raised. The raised numbers of circulating ROS-positive WBC and platelets amplify oxidative stress in CHF.
Published online:
28 October 2008
doi:10.1038/ncpcardio1364 |
Full Text | PDF (674K)
Retrospective study to identify predictors of the presence and rapid progression of aortic dilatation in patients with bicuspid aortic valves
Aortic dilatation is common among adults with bicuspid aortic valves (BAV). Predictors of risk and progression of aortic dilatation are not well described in this setting. In this retrospective analysis the authors study data on the presence of dilation in several aortic segments in 156 adult patients with BAV who had serial echocardiograms performed at least 1 year apart. Their data shows that patients with BAV and increased age, high body surface area, and moderate to severe aortic regurgitation are more likely to have a dilated aorta. Patients with right-to-left leaflet fusion are at increased risk of rapid aortic dilatation.
Published online:
21 October 2008
doi:10.1038/ncpcardio1369 |
Full Text | PDF (321K)
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Until print versions of AOP papers are published, they should be cited in the style "Authorname A et al. (year) Title of article. Nat Clin Pract Cardiovasc Med, advance online publication, day month year [doi:10.1038/ncpcardioxxxx]". Once the print version (identical to the AOP) is published, it should be cited as follows: "Authorname A et al. (year) Title of article. Nat Clin Pract Cardiovasc Med Vol: xxx–xxx, advance online publication, [doi:10.1038/ncpcardioxxxx]".
