Review

Nature Clinical Practice Rheumatology (2008) 4, 404-412
doi:10.1038/ncprheum0855  
Received 18 February 2008 | Accepted 12 May 2008 | Published online: 1 July 2008

Control of autoimmune diseases by the vitamin D endocrine system

Luciano Adorini* and Giuseppe Penna

Correspondence *Intercept Pharmaceuticals, Via P. Togliatti 22 bis, 06073 Corciano (Perugia), Italy

Email
 ladorini@interceptpharma.com

The vitamin D system has both pathophysiological and therapeutic importance for autoimmune disease. In this Review, the authors discuss the role of the vitamin D system in autoimmunity, the mechanistic basis for this role, and present the potential of vitamin D receptor agonists to treat or prevent autoimmune diseases.

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