A signature trial?

Nayanah Siva

doi:10.1038/ncpuro1240 | Full Text | PDF (100K)

Prostate cancer: adenovirus-mediated imaging of sentinel node metastasis

doi:10.1038/ncpuro1207 | Full Text | PDF (75K)

Infertility due to C. trachomatis and Mycoplasma is a result of sperm DNA fragmentation

doi:10.1038/ncpuro1221 | Full Text | PDF (75K)

A poxvirus vaccine improves survival in men with castration-resistant prostate cancer

doi:10.1038/ncpuro1222 | Full Text | PDF (85K)

Serum calcium levels might predict the development of prostate cancer

doi:10.1038/ncpuro1223 | Full Text | PDF (73K)

Patients with bladder cancer have good short-term outcomes after robotic radical cystectomy

doi:10.1038/ncpuro1225 | Full Text | PDF (83K)

NSAIDs and acetaminophen might reduce serum PSA levels

doi:10.1038/ncpuro1226 | Full Text | PDF (73K)

Reduced risk of prostate cancer in men with diabetes is not due to antidiabetic therapy

doi:10.1038/ncpuro1227 | Full Text | PDF (73K)

Novel laparoscopic technique permits 'scar-free' donor nephrectomy

doi:10.1038/ncpneph0933 | Full Text | PDF (74K)

PKA overexpression predicts treatment outcome in men with prostate cancer

doi:10.1038/ncponc1233 | Full Text | PDF (74K)

What is the role of androgen deprivation therapy in the treatment of locally advanced prostate cancer?

Marisa A Kollmeier and Michael J Zelefsky

doi:10.1038/ncpuro1217 | Full Text | PDF (139K)

Are female lower urinary tract symptoms alleviated by -adrenoreceptor antagonists?

Karl-Erik Andersson

doi:10.1038/ncpuro1224 | Full Text | PDF (143K)

Controversies in antimicrobial prophylaxis for urologic surgery: more up-to-date evidence is needed

Shingo Yamamoto and Hiroki Shima

doi:10.1038/ncpuro1230 | Full Text | PDF (136K)

Is gene therapy for the treatment of male infertility feasible?

Kim Boekelheide and Mark Sigman

This Viewpoint, which is the first of three articles discussing gene therapy for the treatment of male infertility, considers the feasibility of the approach. Boekelheide and Sigman initially describe the genetic causes of male infertility, and go on to discuss gene therapy approaches, and possible future directions.

doi:10.1038/ncpuro1234 | Full Text | PDF (322K)

Would gene therapy for the treatment of male infertility be safe?

Dolores J Lamb

The second Viewpoint in the series of articles on gene therapy for male infertility evaluates safety aspects. Lamb describes the ideal vector for DNA transfection, and draws on data from previous studies to describe the safety of various vectors under investigation.

doi:10.1038/ncpuro1238 | Full Text | PDF (141K)

Is gene therapy for the treatment of male infertility ethical?

Mark Sheehan

This article on the ethics of gene therapy for male infertility is the third Viewpoint in the article series. Sheehan addresses issues such as 'playing God', patient consent for gene therapy trials, eugenics, and the distribution of medical resources.

doi:10.1038/ncpuro1235 | Full Text | PDF (201K)

CYP17 inhibition as a hormonal strategy for prostate cancer

Alison HM Reid, Gerhardt Attard, Elaine Barrie and Johann S de Bono

Androgen receptor activation and signaling have a key role in the pathogenesis of castration-resistant prostate cancer. In this Review, Reid and colleagues assess the possible therapeutic strategy of inhibiting androgen biosynthesis by blocking the function of the enzyme CYP17.

doi:10.1038/ncpuro1237 | Full Text | PDF (244K)

Stem cells in urology

Tamer Aboushwareb and Anthony Atala

Stem cell therapies and regenerative medicine promise to revolutionize the treatment of many urological disorders. Here, Aboushwareb and Atala review the techniques used to generate stem cells for therapeutic applications, and discuss their potential for reconstructing the urinary tract, treating urinary incontinence, understanding prostate dysfunction and restoring fertility.

doi:10.1038/ncpuro1228 | Full Text | PDF (713K)