Nature Clinical Practice Urology Nature Clinical Practice Urology provides urologists with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpuro/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Urology 1743-4270 1743-4289 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Urology http://www.nature.com/includes/rj_globnavimages/ncpuro_logo.gif http://www.nature.com/ncpuro/ A signature trial? http://dx.doi.org/10.1038/ncpuro1240 A signature trial?

Nature Clinical Practice Urology 5, 579 (2008). doi:10.1038/ncpuro1240

Author: Nayanah Siva

]]> A signature trial? Nayanah Siva doi:10.1038/ncpuro1240 Nature Clinical Practice Urology 5, 579 (2008) Nature Clinical Practice Urology 5 11 Editorial 579 579 Prostate cancer: adenovirus-mediated imaging of sentinel node metastasis http://dx.doi.org/10.1038/ncpuro1207 Prostate cancer: adenovirus-mediated imaging of sentinel node metastasis

Nature Clinical Practice Urology 5, 580 (2008). doi:10.1038/ncpuro1207

]]> Prostate cancer: adenovirus-mediated imaging of sentinel node metastasis doi:10.1038/ncpuro1207 Nature Clinical Practice Urology 5, 580 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 580 580 Infertility due to C. trachomatis and Mycoplasma is a result of sperm DNA fragmentation http://dx.doi.org/10.1038/ncpuro1221 Infertility due to C. trachomatis and Mycoplasma is a result of sperm DNA fragmentation

Nature Clinical Practice Urology 5, 580 (2008). doi:10.1038/ncpuro1221

]]> Infertility due to C. trachomatis and Mycoplasma is a result of sperm DNA fragmentation doi:10.1038/ncpuro1221 Nature Clinical Practice Urology 5, 580 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 580 580 A poxvirus vaccine improves survival in men with castration-resistant prostate cancer http://dx.doi.org/10.1038/ncpuro1222 A poxvirus vaccine improves survival in men with castration-resistant prostate cancer

Nature Clinical Practice Urology 5, 580 (2008). doi:10.1038/ncpuro1222

]]> A poxvirus vaccine improves survival in men with castration-resistant prostate cancer doi:10.1038/ncpuro1222 Nature Clinical Practice Urology 5, 580 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 580 581 Serum calcium levels might predict the development of prostate cancer http://dx.doi.org/10.1038/ncpuro1223 Serum calcium levels might predict the development of prostate cancer

Nature Clinical Practice Urology 5, 581 (2008). doi:10.1038/ncpuro1223

]]> Serum calcium levels might predict the development of prostate cancer doi:10.1038/ncpuro1223 Nature Clinical Practice Urology 5, 581 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 581 581 Patients with bladder cancer have good short-term outcomes after robotic radical cystectomy http://dx.doi.org/10.1038/ncpuro1225 Patients with bladder cancer have good short-term outcomes after robotic radical cystectomy

Nature Clinical Practice Urology 5, 581 (2008). doi:10.1038/ncpuro1225

]]> Patients with bladder cancer have good short-term outcomes after robotic radical cystectomy doi:10.1038/ncpuro1225 Nature Clinical Practice Urology 5, 581 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 581 582 NSAIDs and acetaminophen might reduce serum PSA levels http://dx.doi.org/10.1038/ncpuro1226 NSAIDs and acetaminophen might reduce serum PSA levels

Nature Clinical Practice Urology 5, 582 (2008). doi:10.1038/ncpuro1226

]]> NSAIDs and acetaminophen might reduce serum PSA levels doi:10.1038/ncpuro1226 Nature Clinical Practice Urology 5, 582 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 582 582 Reduced risk of prostate cancer in men with diabetes is not due to antidiabetic therapy http://dx.doi.org/10.1038/ncpuro1227 Reduced risk of prostate cancer in men with diabetes is not due to antidiabetic therapy

Nature Clinical Practice Urology 5, 582 (2008). doi:10.1038/ncpuro1227

]]> Reduced risk of prostate cancer in men with diabetes is not due to antidiabetic therapy doi:10.1038/ncpuro1227 Nature Clinical Practice Urology 5, 582 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 582 582 Novel laparoscopic technique permits 'scar-free' donor nephrectomy http://dx.doi.org/10.1038/ncpneph0933 Novel laparoscopic technique permits 'scar-free' donor nephrectomy

Nature Clinical Practice Urology 5, 583 (2008). doi:10.1038/ncpneph0933

]]> Novel laparoscopic technique permits 'scar-free' donor nephrectomy doi:10.1038/ncpneph0933 Nature Clinical Practice Urology 5, 583 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 583 583 PKA overexpression predicts treatment outcome in men with prostate cancer http://dx.doi.org/10.1038/ncponc1233 PKA overexpression predicts treatment outcome in men with prostate cancer

Nature Clinical Practice Urology 5, 583 (2008). doi:10.1038/ncponc1233

]]> PKA overexpression predicts treatment outcome in men with prostate cancer doi:10.1038/ncponc1233 Nature Clinical Practice Urology 5, 583 (2008) Nature Clinical Practice Urology 5 11 Research Highlights 583 583 What is the role of androgen deprivation therapy in the treatment of locally advanced prostate cancer? http://dx.doi.org/10.1038/ncpuro1217 What is the role of androgen deprivation therapy in the treatment of locally advanced prostate cancer?

Nature Clinical Practice Urology 5, 584 (2008). doi:10.1038/ncpuro1217

Authors: Marisa A Kollmeier & Michael J Zelefsky

]]> What is the role of androgen deprivation therapy in the treatment of locally advanced prostate cancer? Marisa A Kollmeier Michael J Zelefsky doi:10.1038/ncpuro1217 Nature Clinical Practice Urology 5, 584 (2008) 2008-09-23 Nature Clinical Practice Urology 2008-09-23 5 11 Practice Point 584 585 Are female lower urinary tract symptoms alleviated by α-adrenoreceptor antagonists? http://dx.doi.org/10.1038/ncpuro1224 Are female lower urinary tract symptoms alleviated by α-adrenoreceptor antagonists?

Nature Clinical Practice Urology 5, 586 (2008). doi:10.1038/ncpuro1224

Author: Karl-Erik Andersson

]]> Are female lower urinary tract symptoms alleviated by α-adrenoreceptor antagonists? Karl-Erik Andersson doi:10.1038/ncpuro1224 Nature Clinical Practice Urology 5, 586 (2008) 2008-09-30 Nature Clinical Practice Urology 2008-09-30 5 11 Practice Point 586 587 Controversies in antimicrobial prophylaxis for urologic surgery: more up-to-date evidence is needed http://dx.doi.org/10.1038/ncpuro1230 Controversies in antimicrobial prophylaxis for urologic surgery: more up-to-date evidence is needed

Nature Clinical Practice Urology 5, 588 (2008). doi:10.1038/ncpuro1230

Authors: Shingo Yamamoto & Hiroki Shima

]]> Controversies in antimicrobial prophylaxis for urologic surgery: more up-to-date evidence is needed Shingo Yamamoto Hiroki Shima doi:10.1038/ncpuro1230 Nature Clinical Practice Urology 5, 588 (2008) 2008-10-14 Nature Clinical Practice Urology 2008-10-14 5 11 Practice Point 588 589 Is gene therapy for the treatment of male infertility feasible? http://dx.doi.org/10.1038/ncpuro1234 This Viewpoint, which is the first of three articles discussing gene therapy for the treatment of male infertility, considers the feasibility of the approach. Boekelheide and Sigman initially describe the genetic causes of male infertility, and go on to discuss gene therapy approaches, and possible future directions. Is gene therapy for the treatment of male infertility feasible?

Nature Clinical Practice Urology 5, 590 (2008). doi:10.1038/ncpuro1234

Authors: Kim Boekelheide & Mark Sigman

]]> Is gene therapy for the treatment of male infertility feasible? Kim Boekelheide Mark Sigman doi:10.1038/ncpuro1234 Nature Clinical Practice Urology 5, 590 (2008) 2008-10-14 Nature Clinical Practice Urology 2008-10-14 5 11 Viewpoint 590 593 Would gene therapy for the treatment of male infertility be safe? http://dx.doi.org/10.1038/ncpuro1238 The second Viewpoint in the series of articles on gene therapy for male infertility evaluates safety aspects. Lamb describes the ideal vector for DNA transfection, and draws on data from previous studies to describe the safety of various vectors under investigation. Would gene therapy for the treatment of male infertility be safe?

Nature Clinical Practice Urology 5, 594 (2008). doi:10.1038/ncpuro1238

Author: Dolores J Lamb

]]> Would gene therapy for the treatment of male infertility be safe? Dolores J Lamb doi:10.1038/ncpuro1238 Nature Clinical Practice Urology 5, 594 (2008) 2008-10-14 Nature Clinical Practice Urology 2008-10-14 5 11 Viewpoint 594 595 Is gene therapy for the treatment of male infertility ethical? http://dx.doi.org/10.1038/ncpuro1235 This article on the ethics of gene therapy for male infertility is the third Viewpoint in the article series. Sheehan addresses issues such as 'playing God', patient consent for gene therapy trials, eugenics, and the distribution of medical resources. Is gene therapy for the treatment of male infertility ethical?

Nature Clinical Practice Urology 5, 596 (2008). doi:10.1038/ncpuro1235

Author: Mark Sheehan

]]> Is gene therapy for the treatment of male infertility ethical? Mark Sheehan doi:10.1038/ncpuro1235 Nature Clinical Practice Urology 5, 596 (2008) 2008-10-21 Nature Clinical Practice Urology 2008-10-21 5 11 Viewpoint 596 597 Bacterial biofilms in patients with indwelling urinary catheters http://dx.doi.org/10.1038/ncpuro1231 Bacterial biofilms are common in patients with indwelling urinary catheters, and crystalline biofilms in particular can cause serious complications. In this Review, Stickler describes the biological, physical and chemical factors that can lead to crystalline biofilm formation, and the current and potential future management of crystalline biofilms. Bacterial biofilms in patients with indwelling urinary catheters

Nature Clinical Practice Urology 5, 598 (2008). doi:10.1038/ncpuro1231

Author: David J Stickler

]]> Bacterial biofilms in patients with indwelling urinary catheters David J Stickler doi:10.1038/ncpuro1231 Nature Clinical Practice Urology 5, 598 (2008) 2008-10-14 Nature Clinical Practice Urology 2008-10-14 5 11 Review 598 608 CYP17 inhibition as a hormonal strategy for prostate cancer http://dx.doi.org/10.1038/ncpuro1237 Androgen receptor activation and signaling have a key role in the pathogenesis of castration-resistant prostate cancer. In this Review, Reid and colleagues assess the possible therapeutic strategy of inhibiting androgen biosynthesis by blocking the function of the enzyme CYP17. CYP17 inhibition as a hormonal strategy for prostate cancer

Nature Clinical Practice Urology 5, 610 (2008). doi:10.1038/ncpuro1237

Authors: Alison HM Reid, Gerhardt Attard, Elaine Barrie & Johann S de Bono

]]> CYP17 inhibition as a hormonal strategy for prostate cancer Alison HM Reid Gerhardt Attard Elaine Barrie Johann S de Bono doi:10.1038/ncpuro1237 Nature Clinical Practice Urology 5, 610 (2008) Nature Clinical Practice Urology 5 11 Review 610 620 Stem cells in urology http://dx.doi.org/10.1038/ncpuro1228 Stem cell therapies and regenerative medicine promise to revolutionize the treatment of many urological disorders. Here, Aboushwareb and Atala review the techniques used to generate stem cells for therapeutic applications, and discuss their potential for reconstructing the urinary tract, treating urinary incontinence, understanding prostate dysfunction and restoring fertility. Stem cells in urology

Nature Clinical Practice Urology 5, 621 (2008). doi:10.1038/ncpuro1228

Authors: Tamer Aboushwareb & Anthony Atala

]]> Stem cells in urology Tamer Aboushwareb Anthony Atala doi:10.1038/ncpuro1228 Nature Clinical Practice Urology 5, 621 (2008) 2008-10-14 Nature Clinical Practice Urology 2008-10-14 5 11 Review 621 631 A case of ectopic dysplastic kidney and ectopic ureter diagnosed by MRI http://dx.doi.org/10.1038/ncpuro1220 This Case Study describes a 14-year-old girl with continuous urinary incontinence after resection of a vaginal septum associated with uterus didelphys. The authors discuss the diagnostic procedures undertaken, and show that MRI was effective, both preoperatively and intraoperatively, in detecting an ectopic ureter and ectopic dysplastic kidney. A case of ectopic dysplastic kidney and ectopic ureter diagnosed by MRI

Nature Clinical Practice Urology 5, 632 (2008). doi:10.1038/ncpuro1220

Authors: David T Duong & Linda MD Shortliffe

]]> A case of ectopic dysplastic kidney and ectopic ureter diagnosed by MRI David T Duong Linda MD Shortliffe doi:10.1038/ncpuro1220 Nature Clinical Practice Urology 5, 632 (2008) 2008-10-07 Nature Clinical Practice Urology 2008-10-07 5 11 Case Study 632 636