Brief Communication abstract
Nature Neuroscience 10, 414 - 416 (2007)
Published online: 11 March 2007 | doi:10.1038/nn1871
Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
Valérie Doyère1,2,
Jacek D
biec2,
Marie-H Monfils2,
Glenn E Schafe3
&
Joseph E LeDoux2
When reactivated, memories enter a labile, protein synthesis–dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.
- Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), Centre National de la Recherche Scientifique (CNRS), UMR8620, Université Paris-Sud, 91405 Orsay, France.
- W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA.
- Department of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, Connecticut 06520-8205, USA.
Correspondence to: Joseph E LeDoux2 e-mail: ledoux@cns.nyu.edu.
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