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April 2007 Volume 10 No 4

Synaptic activity regulates protein synthesis, both locally and in the nucleus. Jordan and colleagues now report that AIDA-1d, a newly identified component of postsynaptic densities, links synaptic activity to nuclear protein synthesis by regulating nucleolar assembly. The cover image is a cultured hippocampal neuron with AIDA-1 labeled in green, the dendritic marker MAP-2 labeled in red, and the nucleus labeled in blue. (pp 399 and 427)

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