Brief Communication abstract
Nature Neuroscience 10, 555 - 557 (2007)
Published online: 1 April 2007 | doi:10.1038/nn1880
Memory consolidation or transformation: context manipulation and hippocampal representations of memory
Gordon Winocur1,2,3,4, Morris Moscovitch1,3,5 & Melanie Sekeres6
The traditional view is that the hippocampus is necessary for retaining memories until they are consolidated in their original form in the neocortex. An alternative view is that the original memory, which is hippocampus- and context-dependent, becomes transformed with time to one that is more schematic and independent of the hippocampus. By manipulating context in two protocols that are widely used to investigate hippocampal-neocortical interactions in memory, we find evidence for the transformation view.
- Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada.
- Department of Psychology, Trent University, 1600 West Bank Drive, Peterborough, Ontario, K9J 7B8, Canada.
- Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, M5S 3G3, Canada.
- Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, M5T 1R8, Canada.
- Department of Psychology, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada.
- Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, Ontario, Canada.
Correspondence to: Gordon Winocur1,2,3,4 e-mail: gwinocur@rotman-baycrest.on.ca
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