Article abstract
Nature Neuroscience 10, 1141 - 1150 (2007)
Published online: 12 August 2007 | Corrected online: 19 August 2007 | doi:10.1038/nn1955
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
Ryan Remedios1, Dhananjay Huilgol1, Bhaskar Saha1, Padmanabhan Hari1, Lahar Bhatnagar1, Thomas Kowalczyk2, Robert F Hevner2,3,4, Yoko Suda5, Shinichi Aizawa5, Toshio Ohshima6,7, Anastassia Stoykova8 & Shubha Tole1
Abstract
The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.
- Department of Biological Sciences, B–304, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India.
- Department of Pathology, University of Washington, Seattle, Washington 98195-7270, USA.
- Center on Human Development and Disability, University of Washington, Seattle, Washington 98195-7270, USA.
- Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195-7270, USA.
- Laboratory for Vertebrate Body Plan, Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, RIKEN, Kobe 650-0047, Japan.
- Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Saitama 351-0198, Japan.
- Department of Life Science and Medical Bio-Science, Waseda University, 3-4-1 Okubo Shinjuku-ku, Tokyo 169-8555, Japan.
- Max-Planck Institute of Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany.
Correspondence to: Shubha Tole1 e-mail: stole@tifr.res.in
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