Brief Communication abstract
Nature Neuroscience 11, 131 - 133 (2008)
Published online: 20 January 2008 | doi:10.1038/nn2038
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Tomoya Matsumoto1, Stefanie Rauskolb1, Martin Polack2, Johannes Klose3,4, Roland Kolbeck3,5, Martin Korte2 & Yves-Alain Barde1,3
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.
- Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Technical University Braunschweig, Mendelssohnstrasse 4, D-38106 Braunschweig, Germany.
- Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany.
- Present addresses: Allianz Risk Transfer, Tödistrasse 61, CH-8002 Zürich, Switzerland.
- MedImmune, One MedImmune Way, Gaithersburg, Maryland 20878, USA.
Correspondence to: Yves-Alain Barde1,3 e-mail: yves.barde@unibas.ch
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