Nature Neuroscience5, 1263 - 1264 (2002)
Published online: 18 November 2002; | doi:10.1038/nn977
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
Emanuela Izzo1, 2, Rémi Martin-Fardon1, 2, George F. Koob1, Friedbert Weiss1
& Pietro Paolo Sanna1
1
Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., CVN12, La Jolla, California 92103, USA
2
The first two authors contributed equally to this work.
Correspondence should be addressed to Pietro Paolo Sanna psanna@scripps.edu
Drug addiction has been linked to protracted functional changes in neural circuits involved in motivation that can lead to drug dependence, craving and relapse1. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signal transduction pathway in long-lasting behavioral sensitization to cocaine in rats, an animal model of the long-lasting functional changes induced by repeated drug use2. Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine.
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