Axon growth inhibition: signals from the p75 neurotrophin receptor
David R. Kaplan
& Freda D. Miller
The authors are from the Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. dkaplan@sickkids.ca or fredam@sickkids.ca
Axon growth after CNS injury is restricted in part by several inhibitors found in myelin. The inhibition requires interaction of the Nogo receptor with the p75 neurotrophin receptor. A new paper now shows that the Rho inhibitor Rho-GDI mediates this signaling.
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mediates this signaling.
