Crystallizing our understanding of partial agonists
David S Weiss
& Yongchang Chang
David S Weiss and Yongchang Chang are in the Department of Neurobiology, University of Alabama at Birmingham, 1719 Sixth Avenue. South CIRC410, Birmingham, Alabama 35294, USA. dweiss@nrc.uab.edu
A powerful combination of X-ray crystallography and single-channel current measurements provides new insights into the mechanism by which the binding of agonists opens the AMPA-type glutamate receptor in the central nervous system.
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