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News and Views
Nature Neuroscience 9, 593 - 594 (2006)
doi:10.1038/nn0506-593

LTP: AMPA receptors trading places

Julie A Kauer1 & Robert C Malenka2

1  Julie Kauer is in the Departments of Pharmacology, Physiology and Biotechnology, and Neuroscience, Brown University, Providence, Rhode Island 02912, USA.

2  Robert Malenka is in the Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Rd., Room P105, Palo Alto, California 94304, USA. malenka@stanford.edu

Many forms of LTP involve insertion of new postsynaptic AMPA receptors. Plant et al. now report transient insertion of Ca2+-permeable AMPA receptors after LTP induction, and find their activation is required for LTP maintenance.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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