Nature Neuroscience 9, 993 - 995 (2006)
Published online: 16 July 2006; | doi:10.1038/nn1742
IGF-1 receptor is essential for the establishment of hippocampal neuronal polarityLucas Sosa1, Sebastian Dupraz1, Lisandro Laurino1, Flavia Bollati2, Mariano Bisbal2, Alfredo Cáceres2, Karl H Pfenninger3 &
Santiago Quiroga11
Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba y Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), Consejo de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina. 2
Instituto de Investigaciones Mercedes y Martin Ferreyra (INIMEC-CONICET), Córdoba, Argentina. 3
Department of Pediatrics, University of Colorado School of Medicine and University of Colorado Cancer Center, Aurora, Colorado 80045, USA.
Correspondence should be addressed to Santiago Quiroga squiroga@dqbfcq.uncor.edu IGF-1PI3kCdc42TrkATrkBHow a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.
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