Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationBrief Communications
Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
Jerylin O Gan, Mark E Walton & Paul E M Phillips
Published online: 10 November 2009 | doi:10.1038/nn.2460
Cue-evoked activity of midbrain dopamine neurons is proposed to encode the magnitude, delay and uncertainty of predicted rewards. Here the authors report that this activity separates costs and benefits, as it does not encode the costs of the action required to obtain predicted rewards.
Abstract - | Full Text - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine | PDF (364 KB) - Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine | Supplementary information
Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons
Judit K Makara, Attila Losonczy, Quan Wen & Jeffrey C Magee
Published online: 08 November 2009 | doi:10.1038/nn.2428
Dendritic excitability is a plastic property of neurons. This study shows that exposure to an enriched environment increases propagation of dendritic sodium spikes in a subset of dendritic branches in CA1 pyramidal neurons. This effect is mediated by localized downregulation of A-type potassium channel function.
Abstract - | Full Text - Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons | PDF (672 KB) - Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons | Supplementary information
Self-generated theta oscillations in the hippocampus
Romain Goutagny, Jesse Jackson & Sylvain Williams
Published online: 01 November 2009 | doi:10.1038/nn.2440
Although numerous in vivo studies have suggested that hippocampal theta oscillations are generated by the extrinsic medial septal input, theoretical studies have suggested that the hippocampus has the minimal feedback circuitry necessary to intrinsically generate its own theta rhythm. Here, Goutagny et al. directly demonstrate such oscillation independently of external inputs.
Abstract - | Full Text - Self-generated theta oscillations in the hippocampus | PDF (2,007 KB) - Self-generated theta oscillations in the hippocampus | Supplementary information
The pathways of interoceptive awareness
Sahib S Khalsa, David Rudrauf, Justin S Feinstein & Daniel Tranel
Published online: 01 November 2009 | doi:10.1038/nn.2411
Studying a patient with selective damage to the insular and anterior cingulate cortex, the current study finds that these regions are not necessary for interoceptive awareness of one's own heartbeat, but the primary somatosensory cortex is required for such self-awareness.
Abstract - | Full Text - The pathways of interoceptive awareness | PDF (950 KB) - The pathways of interoceptive awareness | Supplementary information
Articles
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
Celia Andreu-Agulló, José Manuel Morante-Redolat, Ana C Delgado & Isabel Fariñas
Published online: 08 November 2009 | doi:10.1038/nn.2437
Notch signaling is essential for the maintenance of adult neural stem cells in vivo. Here, Andreu-Agulló and colleagues show that PEDF, released from endothelial cells, enhances Notch signaling in the mouse subependymal zone by inactivating a repressor of Notch target genes.
Abstract - | Full Text - Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone | PDF (1,580 KB) - Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone | Supplementary information
Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements
Yoshikazu Isomura, Rie Harukuni, Takashi Takekawa, Hidenori Aizawa & Tomoki Fukai
Published online: 08 November 2009 | doi:10.1038/nn.2431
Systematically monitoring the activities of various cortical pyramidal neurons and interneurons during different stages of locomotion, the authors characterize differential firing activities of motor cortex microcircuitry in behaving, head-restraint rats that were trained to push, pull or hold a lever for reward.
Abstract - | Full Text - Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements | PDF (1,205 KB) - Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements | Supplementary information
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Chris Murgatroyd, Alexandre V Patchev, Yonghe Wu, Vincenzo Micale, Yvonne Bockmühl, Dieter Fischer, Florian Holsboer, Carsten T Wotjak, Osborne F X Almeida & Dietmar Spengler
Published online: 08 November 2009 | doi:10.1038/nn.2436
Severe stress in early childhood can increase an individual's vulnerability to depression later in life. This study found that early-life stress in mice resulted in persistent elevation of the stress hormone arginine vasopressin (AVP), which was caused by persistent hypomethylation of CpG islands in the Avp promoter in the hypothalamus.
Abstract - | Full Text - Dynamic DNA methylation programs persistent adverse effects of early-life stress | PDF (834 KB) - Dynamic DNA methylation programs persistent adverse effects of early-life stress | Supplementary information
Adult generation of glutamatergic olfactory bulb interneurons
Monika S Brill, Jovica Ninkovic, Eleanor Winpenny, Rebecca D Hodge, Ilknur Ozen, Roderick Yang, Alexandra Lepier, Sergio Gascón, Ferenc Erdelyi, Gabor Szabo, Carlos Parras, Francois Guillemot, Michael Frotscher, Benedikt Berninger, Robert F Hevner, Olivier Raineteau & Magdalena Götz
Published online: 01 November 2009 | doi:10.1038/nn.2416
Neural stem cells in the adult mouse SVZ are thought to only generate GABAergic olfactory bulb interneurons. This study reports that a dorsal region of the adult SVZ gives rise to a glutamatergic type of olfactory bulb neurons. These newborn glutamatergic neurons can be diverted to migrate into the cortex towards an injury, possibly contributing to repair.
Abstract - | Full Text - Adult generation of glutamatergic olfactory bulb interneurons | PDF (2,303 KB) - Adult generation of glutamatergic olfactory bulb interneurons | Supplementary information
A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning
Daniel Kirilly, Ying Gu, Yafen Huang, Zhuhao Wu, Arash Bashirullah, Boon Chuan Low, Alex L Kolodkin, Hongyan Wang & Fengwei Yu
Published online: 01 November 2009 | doi:10.1038/nn.2415
Certain Drosophila dendrites undergo major remodeling during metamorphosis. This study shows that the severing of larval dendrites, which is the first step of remodeling, depends on the upregulation of the cytoskeleton-binding protein Mical by the transcription factor Sox14.
Abstract - | Full Text - A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning | PDF (1,577 KB) - A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning | Supplementary information
Input normalization by global feedforward inhibition expands cortical dynamic range
Frédéric Pouille, Antonia Marin-Burgin, Hillel Adesnik, Bassam V Atallah & Massimo Scanziani
Published online: 01 November 2009 | doi:10.1038/nn.2441
The cortex is sensitive to weak stimuli, but also responds to stronger inputs without saturating. In this study, Scanziani and colleagues find some of the circuits that enable neuronal populations to respond to a wide range of input strengths.
Abstract - | Full Text - Input normalization by global feedforward inhibition expands cortical dynamic range | PDF (1,128 KB) - Input normalization by global feedforward inhibition expands cortical dynamic range | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Neuroscience advance online publication, day month year (doi:10.1038/neuroXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Neuroscience volume, page (year); advance online publication, (doi:10.1038/neuroXXXXX)".
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