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Published online 30 July 2008 | Nature 454, 565-569 (2008) | doi:10.1038/454565a

News Feature

HIV: The next shot

Researchers trying to develop an HIV vaccine have endured two decades of setbacks. Erika Check Hayden meets a veteran still engaged in the fight — and a rookie willing to join in anyway.

As Larry Corey boarded a plane on the night of 18 September 2007, he was in shock. For four years, he had been in charge of clinical trials of a vaccine against HIV.

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