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Published online 20 May 2009 | Nature 459, 310 (2009) | doi:10.1038/459310a

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Alzheimer's theory makes a splash

Neuroscientists probe idea that neuronal pruning may contribute to degenerative disorder.

The Alzheimer's research community is buzzing about a theory suggesting that a close relative of the beta-amyloid protein, and not necessarily beta-amyloid itself — the long-standing suspect — may be a major culprit in the disease.

The theory holds that an amyloid-related mechanism that prunes neuronal connections in the brain in the fast-growth phase of early life may be triggered by ageing-related processes in later life to cause the neuronal withering of Alzheimer's disease ("A.

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    • 25 May, 2009
    • Posted by: Shin jaehyun