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Journal home Advance online publication Current issue Archive Press releases Free Association (blog) Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Biotechnology Nature Cell Biology Nature Medicine Nature Methods Nature Reviews Cancer Nature Reviews Genetics Nature Reviews Molecular Cell Biology news@nature.com Nature Conferences RNAi Gateway NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Genetics  34, 8 - 9 (2003) doi:10.1038/ng0503-8 ORFeomics: correcting the wiggle in worm genes Charles Boone1, 2 & Brenda Andrews2 1  Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 1A8 Canada. 2  Department of Medical Genetics & Microbiology, University of Toronto, Toronto, Ontario M5S 1A8 Canada. Correspondence should be addressed to Charles Boone charlie.boone@utoronto.ca or Brenda Andrews brenda.andrews@utoronto.caA new study attempts to amplify and clone all the predicted protein-encoding open reading frames (ORFs) for Caenorhabditis elegans. This analysis confirms many of the predicted genes but suggests roughly 50% of them require correction. Recombining the ORFs into a number of different expression systems can generate functional proteomics kits for characterizing protein activity and interaction networks. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated NEWS AND VIEWS In Brief Nature Biotechnology Research News (01 May 2003) RESEARCH C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression Nature Genetics Article (01 May 2003) Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans Nature Genetics Letters (01 Mar 2001)  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... Novel Approaches to Protecting Maize from Insect Damage Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... More Challenges Powered by: nature jobs Manager / Sr. Manager - Business Development (Custom Synthesis) Syngene International Bangalore, Karnataka 560099 India Sr. Scientific Manager / Chief Scientific Manager- Discovery Metabolism and Pharmacokinetics (MAP) Syngene International Bangalore, Karnataka 560099 India More science jobs Post a job for free See also: Article by Reboul et al. Export citation Search buyers guide:   ADVERTISEMENT

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