A keaper and a striker maintain epidermal homeostasis
Thomas M Magin
Thomas M. Magin is at the Institut fuer Physiologische Chemie, Abteilung fuer Zellbiochemie, and LIMES, Rheinische Friedrich-Wilhelms-Universitaet, Nussallee 11, D-53115 Bonn, Germany. t.magin@uni-bonn.de
The actin-associated kelch-domain protein Keap1 acts upstream of the transcription factor Nrf2. Upon stress, Keap1 releases Nrf2 to activate the transcription of target genes. A new study now shows that these targets include keratins and cornified envelope proteins, possibly explaining why certain keratin mutations predispose to chemical injury. The Keap1-Nrf2 partnership offers a mechanistic explanation for the response of tissues to mechanical and chemical injury.
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