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News and Views
Nature Genetics  37, 214 - 215 (2005)
doi:10.1038/ng0305-214

Dissecting dispensability

Laurence D Hurst1 & Csaba Pál2

1  Laurence Hurst is in the Department of Biology and Biochemistry, University of Bath, UK. l.d.hurst@bath.ac.uk

2  Csaba Pál is at MTA, Theoretical Biology Research Group, Eotvos Lorand University, Budapest, Hungary

Like most organisms, yeast has relatively few genes that are necessary for viability. The presence of a duplicate gene elsewhere in the genome underpins many cases of dispensability. A new study suggests that the backup mechanism is more complex than previously assumed and requires feedback loops that ensure transcriptional upregulation of the duplicate.

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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