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Journal home Advance online publication Current issue Archive Press releases Free Association (blog) Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Biotechnology Nature Cell Biology Nature Medicine Nature Methods Nature Reviews Cancer Nature Reviews Genetics Nature Reviews Molecular Cell Biology news@nature.com Nature Conferences RNAi Gateway NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Perspective Nature Genetics 38, S2 - S7 (2006) Published online: ; | doi:10.1038/ng1794 Approaches to microRNA discovery Eugene Berezikov, Edwin Cuppen & Ronald H A Plasterk Eugene Berezikov, Edwin Cuppen and Ronald H.A. Plasterk are in the Hubrecht Laboratory, Uppsalalaan 8, 3584CT Utrecht, The Netherlands. plasterk@niob.knaw.nl MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation Nature Structural & Molecular Biology News and Views (01 Jul 2007) RESEARCH Application of array CGH on archival formalin-fixed paraffin-embedded tissues including small numbers of microdissected cells Laboratory Investigation Technical Report MicroRNA expression profiles of human leukemias Leukemia Letter Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs Nature Structural & Molecular Biology Article (01 Feb 2009) See all 44 matches for Research  Top Abstract | Next Table of contents Full text Download PDF Send to a friend Rights and permissions Order commercial reprints CrossRef lists 31 articles citing this article Save this link Figures & Tables Export citation Open Innovation Challenges Novel Approaches to Protecting Maize from Insect Damage Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... More Challenges Powered by: nature jobs Bacterial Geneticist / Microbiologist TCG Lifesciences Ltd Kolkata India Senior Research Assistant / Laboratory Manager – Team 27 - Ref: 80469 Wellcome Trust Sanger Institute Hinxton Cambridge CB10 1SA UK More science jobs Post a job for free Search buyers guide:

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