Nature Genetics 38, 738 - 740 (2006)
doi:10.1038/ng0706-738
CIMPle origin for promoter hypermethylation in colorectal cancer?Kornel Schuebel, Wei Chen & Stephen B Baylin
Kornel Schuebel, Wei Chen and Stephen B. Baylin are in the Division of Cancer Biology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland, USA. sbaylin@jhmi.edu
The proposal that a distinct subset of colorectal cancers show a marked propensity for promoter CpG island DNA methylation and associated gene silencing has been hotly debated. A new study takes an unbiased approach and not only strongly concludes that a CpG island methylator phenotype exists, but also offers new markers to define a concept that could teach much about the origins of cancer.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|
