Genomics of common diseases - p569

doi:10.1038/ng0507-569

Full Text - Genomics of common diseases | PDF (54 KB) - Genomics of common diseases

Reactive oxygen species and the segregation of mtDNA sequence variants - pp571 - 572

Brendan J Battersby & Eric A Shoubridge

doi:10.1038/ng0507-571

Full Text - Reactive oxygen species and the segregation of mtDNA sequence variants | PDF (90 KB) - Reactive oxygen species and the segregation of mtDNA sequence variants

Reply to "Reactive oxygen species and the segregation of mtDNA sequence variants" - p572

José A Enriquez, Raquel Moreno-Loshuertos, Rebeca Acín-Pérez, Nieves Movilla, M Esther Gallardo, Santiago Rodriguez de Córdoba, Acisclo Pérez-Martos & Patricio Fernández-Silva

doi:10.1038/ng0507-572

Full Text - Reply to "Reactive oxygen species and the segregation of mtDNA sequence variants" | PDF (76 KB) - Reply to "Reactive oxygen species and the segregation of mtDNA sequence variants"

Inherited epimutation or a haplotypic basis for the propensity to silence? - p573

Catherine M Suter & David I K Martin

doi:10.1038/ng0507-573a

Full Text - Inherited epimutation or a haplotypic basis for the propensity to silence? | PDF (76 KB) - Inherited epimutation or a haplotypic basis for the propensity to silence?

Heritable germline epimutations in humans - pp573 - 574

Bernhard Horsthemke

doi:10.1038/ng0507-573b

Full Text - Heritable germline epimutations in humans | PDF (87 KB) - Heritable germline epimutations in humans

Heritable germline epimutation is not the same as transgenerational epigenetic inheritance - pp574 - 575

Suyinn Chong, Neil A Youngson & Emma Whitelaw

doi:10.1038/ng0507-574

Full Text - Heritable germline epimutation is not the same as transgenerational epigenetic inheritance | PDF (89 KB) - Heritable germline epimutation is not the same as transgenerational epigenetic inheritance

Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance" - pp575 - 576

Catherine M Suter & David IK Martin

doi:10.1038/ng0507-575

Full Text - Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance" | PDF (88 KB) - Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance"

Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance" - p576

Suet Y Leung, Tsun L Chan & Siu T Yuen

doi:10.1038/ng0507-576

Full Text - Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance" | PDF (72 KB) - Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance"

Genes get diabolical - p577

doi:10.1038/ng0507-577

Full Text - Genes get diabolical | PDF (99 KB) - Genes get diabolical

Multiple prostate cancer risk variants on 8q24 - pp579 - 580

John S Witte

doi:10.1038/ng0507-579

Full Text - Multiple prostate cancer risk variants on 8q24 | PDF (151 KB) - Multiple prostate cancer risk variants on 8q24

See also: Letter by Gudmundsson et al. | Letter by Haiman et al. | Letter by Yeager et al.

Road rage and fruit flies - pp581 - 582

Anne F Simon & David E Krantz

doi:10.1038/ng0507-581

Full Text - Road rage and fruit flies | PDF (120 KB) - Road rage and fruit flies

See also: Letter by Dierick & Greenspan

MicroRNAs as tumor suppressors - pp582 - 583

Scott M Hammond

doi:10.1038/ng0507-582

Full Text - MicroRNAs as tumor suppressors | PDF (141 KB) - MicroRNAs as tumor suppressors

See also: Letter by Kumar et al.

A quantitative trait locus regulating rice grain width - pp583 - 584

Makoto Matsuoka & Motoyuki Ashikari

doi:10.1038/ng0507-583

Full Text - A quantitative trait locus regulating rice grain width | PDF (392 KB) - A quantitative trait locus regulating rice grain width

See also: Article by Song et al.

Touching base - p585

doi:10.1038/ng0507-585

Full Text - Touching base | PDF (135 KB) - Touching base

Research highlights - p587

doi:10.1038/ng0507-587

Full Text - Research highlights | PDF (67 KB) - Research highlights

Drosophila researchers focus on human disease - p589

Juan Botas

doi:10.1038/ng0507-589

Full Text - Drosophila researchers focus on human disease | PDF (191 KB) - Drosophila researchers focus on human disease

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia - pp593 - 595

Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink & Jan Cools

doi:10.1038/ng2025

Abstract - Duplication of the : MYB: oncogene in T cell acute lymphoblastic leukemia | Full Text - Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia | PDF (163 KB) - Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia | Supplementary information

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis - pp596 - 604

John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta, Yin Yao Shugart, Anne M Griffiths, Stephan R Targan, Andrew F Ippoliti, Edmond-Jean Bernard, Ling Mei, Dan L Nicolae, Miguel Regueiro, L Philip Schumm, A Hillary Steinhart, Jerome I Rotter, Richard H Duerr, Judy H Cho, Mark J Daly & Steven R Brant

doi:10.1038/ng2032

Abstract - Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Full Text - Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | PDF (543 KB) - Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Supplementary information

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers - pp605 - 613

Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng & Dongxin Lin

doi:10.1038/ng2030

Abstract - A six-nucleotide insertion-deletion polymorphism in the : CASP8: promoter is associated with susceptibility to multiple cancers | Full Text - A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers | PDF (381 KB) - A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers | Supplementary information

Modifiers of epigenetic reprogramming show paternal effects in the mouse - pp614 - 622

Suyinn Chong, Nicola Vickaryous, Alyson Ashe, Natasha Zamudio, Neil Youngson, Sarah Hemley, Tomas Stopka, Arthur Skoultchi, Jacqui Matthews, Hamish S Scott, David de Kretser, Moira O'Bryan, Marnie Blewitt & Emma Whitelaw

doi:10.1038/ng2031

Abstract - Modifiers of epigenetic reprogramming show paternal effects in the mouse | Full Text - Modifiers of epigenetic reprogramming show paternal effects in the mouse | PDF (595 KB) - Modifiers of epigenetic reprogramming show paternal effects in the mouse | Supplementary information

A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase - pp623 - 630

Xian-Jun Song, Wei Huang, Min Shi, Mei-Zhen Zhu & Hong-Xuan Lin

doi:10.1038/ng2014

Abstract - A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase | Full Text - A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase | PDF (678 KB) - A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase | Supplementary information

See also: News and Views by Matsuoka & Ashikari

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 - pp631 - 637

Julius Gudmundsson, Patrick Sulem, Andrei Manolescu, Laufey T Amundadottir, Daniel Gudbjartsson, Agnar Helgason, Thorunn Rafnar, Jon T Bergthorsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Jianfeng Xu, Thorarinn Blondal, Jelena Kostic, Jielin Sun, Shyamali Ghosh, Simon N Stacey, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Kristleifur Kristjansson, Alejandro Tres, Alan W Partin, Marjo T Albers-Akkers, Javier Godino-Ivan Marcos, Patrick C Walsh, Dorine W Swinkels, Sebastian Navarrete, Sarah D Isaacs, Katja K Aben, Theresa Graif, John Cashy, Manuel Ruiz-Echarri, Kathleen E Wiley, Brian K Suarez, J Alfred Witjes, Mike Frigge, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, Lambertus A Kiemeney, William B Isaacs, William J Catalona, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson

doi:10.1038/ng1999

First paragraph - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 | Full Text - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 | PDF (255 KB) - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 | Supplementary information

See also: News and Views by Witte

Multiple regions within 8q24 independently affect risk for prostate cancer - pp638 - 644

Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson & David Reich

doi:10.1038/ng2015

First paragraph - Multiple regions within 8q24 independently affect risk for prostate cancer | Full Text - Multiple regions within 8q24 independently affect risk for prostate cancer | PDF (554 KB) - Multiple regions within 8q24 independently affect risk for prostate cancer | Supplementary information

See also: News and Views by Witte

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 - pp645 - 649

Meredith Yeager, Nick Orr, Richard B Hayes, Kevin B Jacobs, Peter Kraft, Sholom Wacholder, Mark J Minichiello, Paul Fearnhead, Kai Yu, Nilanjan Chatterjee, Zhaoming Wang, Robert Welch, Brian J Staats, Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun, Carmen Rodriguez, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Edward Giovannucci, Walter C Willett, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, Edward P Gelmann, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Jr, Robert Hoover, David J Hunter, Stephen J Chanock & Gilles Thomas

doi:10.1038/ng2022

First paragraph - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 | Full Text - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 | PDF (388 KB) - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 | Supplementary information

See also: News and Views by Witte

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema - pp650 - 654

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter R Hull, Gráinne M O'Regan, Timothy H Clayton, Rosemarie M Watson, Thomas Carrick, Alan T Evans, Haihui Liao, Yiwei Zhao, Linda E Campbell, Matthias Schmuth, Robert Gruber, Andreas R Janecke, Peter M Elias, Maurice A M van Steensel, Ivo Nagtzaam, Michel van Geel, Peter M Steijlen, Colin S Munro, Daniel G Bradley, Colin N A Palmer, Frances J D Smith, W H Irwin McLean & Alan D Irvine

doi:10.1038/ng2020

First paragraph - Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema | Full Text - Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema | PDF (210 KB) - Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema | Supplementary information

Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer - pp655 - 660

Frederik Holst, Phillip R Stahl, Christian Ruiz, Olaf Hellwinkel, Zeenath Jehan, Marc Wendland, Annette Lebeau, Luigi Terracciano, Khawla Al-Kuraya, Fritz Jänicke, Guido Sauter & Ronald Simon

doi:10.1038/ng2006

First paragraph - Estrogen receptor alpha (: ESR1: ) gene amplification is frequent in breast cancer | Full Text - Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer | PDF (326 KB) - Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer | Supplementary information

Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility - pp661 - 665

Klaus Dieterich, Ricardo Soto Rifo, Anne Karen Faure, Sylviane Hennebicq, Baha Ben Amar, Mohamed Zahi, Julia Perrin, Delphine Martinez, Bernard Sèle, Pierre-Simon Jouk, Théophile Ohlmann, Sophie Rousseaux, Joel Lunardi & Pierre F Ray

doi:10.1038/ng2027

First paragraph - Homozygous mutation of : AURKC: yields large-headed polyploid spermatozoa and causes male infertility | Full Text - Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility | PDF (209 KB) - Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility | Supplementary information

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models - pp666 - 672

Marc-Emmanuel Dumas, Steven P Wilder, Marie-Thérèse Bihoreau, Richard H Barton, Jane F Fearnside, Karène Argoud, Lisa D'Amato, Robert H Wallis, Christine Blancher, Hector C Keun, Dorrit Baunsgaard, James Scott, Ulla Grove Sidelmann, Jeremy K Nicholson & Dominique Gauguier

doi:10.1038/ng2026

First paragraph - Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models | Full Text - Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models | PDF (495 KB) - Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models | Supplementary information

Impaired microRNA processing enhances cellular transformation and tumorigenesis - pp673 - 677

Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub & Tyler Jacks

doi:10.1038/ng2003

First paragraph - Impaired microRNA processing enhances cellular transformation and tumorigenesis | Full Text - Impaired microRNA processing enhances cellular transformation and tumorigenesis | PDF (314 KB) - Impaired microRNA processing enhances cellular transformation and tumorigenesis | Supplementary information

See also: News and Views by Hammond

Serotonin and neuropeptide F have opposite modulatory effects on fly aggression - pp678 - 682

Herman A Dierick & Ralph J Greenspan

doi:10.1038/ng2029

First paragraph - Serotonin and neuropeptide F have opposite modulatory effects on fly aggression | Full Text - Serotonin and neuropeptide F have opposite modulatory effects on fly aggression | PDF (200 KB) - Serotonin and neuropeptide F have opposite modulatory effects on fly aggression | Supplementary information

See also: News and Views by Simon & Krantz

Genetic reconstruction of a functional transcriptional regulatory network - pp683 - 687

Zhanzhi Hu, Patrick J Killion & Vishwanath R Iyer

doi:10.1038/ng2012

First paragraph - Genetic reconstruction of a functional transcriptional regulatory network | Full Text - Genetic reconstruction of a functional transcriptional regulatory network | PDF (208 KB) - Genetic reconstruction of a functional transcriptional regulatory network | Supplementary information

Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species - p688

Orna Man & Yitzhak Pilpel

doi:10.1038/ng0507-688a

Full Text - Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species | PDF (97 KB) - Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species

Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk - p688

Angela Cox, Alison M Dunning, Montserrat Garcia-Closas, Sabapathy Balasubramanian, Malcolm W R Reed, Karen A Pooley, Serena Scollen, Caroline Baynes, Bruce A J Ponder, Stephen Chanock, Jolanta Lissowska, Louise Brinton, Beata Peplonska, Melissa C Southey, John L Hopper, Margaret R E McCredie, Graham G Giles, Olivia Fletcher, Nichola Johnson, Isabel dos Santos Silva, Lorna Gibson, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Diana Torres, Ute Hamann, Christina Justenhoven, Hiltrud Brauch, Jenny Chang-Claude, Silke Kropp, Angela Risch, Shan Wang-Gohrke, Peter Schürmann, Natalia Bogdanova, Thilo Dörk, Rainer Fagerholm, Kirsimari Aaltonen, Carl Blomqvist, Heli Nevanlinna, Sheila Seal, Anthony Renwick, Michael R Stratton, Nazneen Rahman, Suleeporn Sangrajrang, David Hughes, Fabrice Odefrey, Paul Brennan, Amanda B Spurdle, Georgia Chenevix-Trench, The Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, Jonathan Beesley, Arto Mannermaa, Jaana Hartikainen, Vesa Kataja, Veli-Matti Kosma, Fergus J Couch, Janet E Olson, Ellen L Goode, Annegien Broeks, Marjanka K Schmidt, Frans B L Hogervorst, Laura J Van't Veer, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Sara Wedrén, Per Hall, Yen-Ling Low, Jianjun Liu, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, Alice J Sigurdson, Denise L Stredrick, Bruce H Alexander, Jeffery P Struewing, Paul D P Pharoah & Douglas F Easton, on behalf of the Breast Cancer Association Consortium

doi:10.1038/ng0507-688b

Full Text - Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk | PDF (97 KB) - Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk