Starting well in Europe - p485

doi:10.1038/ng0508-485

Despite a reputation for impenetrable bureaucracy, the European Union has in place two relatively elegant funding mechanisms for the critical transitions of a scientist's career: for the PhD moving into postdoctoral research, and for outstanding researchers launching their first independent research programs.

Abstract - | Full Text - Starting well in Europe | PDF (77 KB) - Starting well in Europe

Joshua Lederberg 1925–2008 - p486

James F Crow

doi:10.1038/ng0508-486

Full Text - Joshua Lederberg 1925–2008 | PDF (80 KB) - Joshua Lederberg 1925–2008

The beginning of the ends - p487

Susan L Forsburg reviews Elizabeth Blackburn and the Story of Telomeres by Catherine Brady

doi:10.1038/ng0508-487

Full Text - The beginning of the ends | PDF (114 KB) - The beginning of the ends

Sizing up human height variation - pp489 - 490

Peter M Visscher

doi:10.1038/ng0508-489

Genome-wide association studies have identified many variants affecting susceptibility to disease. Now, three studies use this approach to study adult height variation in a combined sample size of 63,000 individuals and report a total of 54 validated variants influencing this trait.

Abstract - | Full Text - Sizing up human height variation | PDF (130 KB) - Sizing up human height variation

See also: Article by Weedon et al. | Article by Lettre et al. | Letter by Gudbjartsson et al.

Principal component analysis of genetic data - pp491 - 492

David Reich, Alkes L Price & Nick Patterson

doi:10.1038/ng0508-491

Principal component analysis (PCA) has been a useful tool for analysis of genetic data, particularly in studies of human migration. A new study finds evidence that the observed geographic gradients, traditionally thought to represent major historical migrations, may in fact have other interpretations.

Abstract - | Full Text - Principal component analysis of genetic data | PDF (463 KB) - Principal component analysis of genetic data

See also: Letter by Novembre & Stephens

From gene expression to disease risk - pp492 - 493

Emmanouil T Dermitzakis

doi:10.1038/ng0508-492

Gene expression can be an indicator of cellular state, and studies characterizing variation in gene expression have been useful on the cellular level. Two new studies now provide the first direct demonstration of the successful use of the multidimensionality of gene expression to dissect the genetic architecture of complex diseases.

Abstract - | Full Text - From gene expression to disease risk | PDF (195 KB) - From gene expression to disease risk

Coevolution in the tumor microenvironment - pp494 - 495

Robert A Weinberg

doi:10.1038/ng0508-494

The progression of carcinomas to high-grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma undergo genetic alterations during this progression, a new study now provides evidence that strongly contradicts this theory of stromal cell coevolution.

Abstract - | Full Text - Coevolution in the tumor microenvironment | PDF (195 KB) - Coevolution in the tumor microenvironment

See also: Letter by Qiu et al.

Salt wasting and blood pressure - pp495 - 496

Olivier Devuyst

doi:10.1038/ng0508-495

Recessive loss-of-function mutations in genes involved in renal NaCl handling cause rare diseases characterized by salt wasting and reduced blood pressure of variable severity. A new study shows that the carrier state for rare inactivating mutations in three genes involved in NaCl transport in the kidney is associated with a significant blood pressure reduction and a reduced risk of hypertension in the general population.

Abstract - | Full Text - Salt wasting and blood pressure | PDF (344 KB) - Salt wasting and blood pressure

See also: Article by Ji et al.

Research Highlights - p497

doi:10.1038/ng0508-497

Full Text - Research Highlights | PDF (68 KB) - Research Highlights

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors - pp499 - 507

Ittai Ben-Porath, Matthew W Thomson, Vincent J Carey, Ruping Ge, George W Bell, Aviv Regev & Robert A Weinberg

doi:10.1038/ng.127

Abstract - | Full Text - An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors | PDF (1,790 KB) - An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors | Supplementary information

Focus onYear of the Rat

Year of the Rat - p513

doi:10.1038/ng0508-513

The usefulness of the rat as a genetic model of complex traits and disease is increasing, with the development of a number of genome-wide resources enabling high-resolution genetic analysis. This special focus on rat genetics surveys the landscape and highlights the range of discoveries that are now possible.

Abstract - | Full Text - Year of the Rat | PDF (87 KB) - Year of the Rat

Focus onYear of the Rat

An ENU-induced mutant archive for gene targeting in rats - pp514 - 515

Tomoji Mashimo, Katsuhiko Yanagihara, Satoko Tokuda, Birger Voigt, Akiko Takizawa, Reiko Nakajima, Megumi Kato, Masumi Hirabayashi, Takashi Kuramoto & Tadao Serikawa

doi:10.1038/ng0508-514

Full Text - An ENU-induced mutant archive for gene targeting in rats | PDF (395 KB) - An ENU-induced mutant archive for gene targeting in rats | Supplementary information

Focus onYear of the Rat

Progress and prospects in rat genetics: a community view - pp516 - 522

Timothy J Aitman, John K Critser, Edwin Cuppen, Anna Dominiczak, Xose M Fernandez-Suarez, Jonathan Flint, Dominique Gauguier, Aron M Geurts, Michael Gould, Peter C Harris, Rikard Holmdahl, Norbert Hubner, Zsuzsanna Izsvák, Howard J Jacob, Takashi Kuramoto, Anne E Kwitek, Anna Marrone, Tomoji Mashimo, Carol Moreno, John Mullins, Linda Mullins, Tomas Olsson, Michal Pravenec, Lela Riley, Kathrin Saar, Tadao Serikawa, James D Shull, Claude Szpirer, Simon N Twigger, Birger Voigt & Kim Worley

doi:10.1038/ng.147

Abstract - | Full Text - Progress and prospects in rat genetics: a community view | PDF (234 KB) - Progress and prospects in rat genetics: a community view | Supplementary information

Focus onYear of the Rat

What everybody should know about the rat genome and its online resources - pp523 - 527

Simon N Twigger, Kim D Pruitt, Xosé M Fernández-Suárez, Donna Karolchik, Kim C Worley, Donna R Maglott, Garth Brown, George Weinstock, Richard A Gibbs, Jim Kent, Ewan Birney & Howard J Jacob

doi:10.1038/ng0508-523

It has been four years since the original publication of the draft sequence of the rat genome. Five groups are now working together to assemble, annotate and release an updated version of the rat genome. As the prevailing model for physiology, complex disease and pharmacological studies, there is an acute need for the rat's genomic resources to keep pace with the rat's prominence in the laboratory. In this commentary, we describe the current status of the rat genome sequence and the plans for its impending 'upgrade'. We then cover the key online resources providing access to the rat genome, including the new SNP views at Ensembl, the RefSeq and Genes databases at the US National Center for Biotechnology Information, Genome Browser at the University of California Santa Cruz and the disease portals for cardiovascular disease and obesity at the Rat Genome Database.

Abstract - | Full Text - What everybody should know about the rat genome and its online resources | PDF (259 KB) - What everybody should know about the rat genome and its online resources | Supplementary information

Focus onYear of the Rat

Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease - pp529 - 537

Jan Monti, Judith Fischer, Svetlana Paskas, Matthias Heinig, Herbert Schulz, Claudia Gösele, Arnd Heuser, Robert Fischer, Cosima Schmidt, Alexander Schirdewan, Volkmar Gross, Oliver Hummel, Henrike Maatz, Giannino Patone, Kathrin Saar, Martin Vingron, Steven M Weldon, Klaus Lindpaintner, Bruce D Hammock, Klaus Rohde, Rainer Dietz, Stuart A Cook, Wolf-Hagen Schunck, Friedrich C Luft & Norbert Hubner

doi:10.1038/ng.129

Abstract - | Full Text - Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease | PDF (448 KB) - Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease | Supplementary information

Focus onYear of the Rat

Distribution and functional impact of DNA copy number variation in the rat - pp538 - 545

Victor Guryev, Kathrin Saar, Tatjana Adamovic, Mark Verheul, Sebastiaan A A C van Heesch, Stuart Cook, Michal Pravenec, Timothy Aitman, Howard Jacob, James D Shull, Norbert Hubner & Edwin Cuppen

doi:10.1038/ng.141

Abstract - | Full Text - Distribution and functional impact of DNA copy number variation in the rat | PDF (452 KB) - Distribution and functional impact of DNA copy number variation in the rat | Supplementary information

Focus onYear of the Rat

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass - pp546 - 552

Enrico Petretto, Rizwan Sarwar, Ian Grieve, Han Lu, Mande K Kumaran, Phillip J Muckett, Jonathan Mangion, Blanche Schroen, Matthew Benson, Prakash P Punjabi, Sanjay K Prasad, Dudley J Pennell, Chris Kiesewetter, Elena S Tasheva, Lolita M Corpuz, Megan D Webb, Gary W Conrad, Theodore W Kurtz, Vladimir Kren, Judith Fischer, Norbert Hubner, Yigal M Pinto, Michal Pravenec, Timothy J Aitman & Stuart A Cook

doi:10.1038/ng.134

First Paragraph - | Full Text - Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass | PDF (445 KB) - Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass | Supplementary information

Focus onYear of the Rat

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility - pp553 - 559

Jacques Behmoaras, Gurjeet Bhangal, Jennifer Smith, Kylie McDonald, Brenda Mutch, Ping Chin Lai, Jan Domin, Laurence Game, Alan Salama, Brian M Foxwell, Charles D Pusey, H Terence Cook & Timothy J Aitman

doi:10.1038/ng.137

First Paragraph - | Full Text - Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility | PDF (327 KB) - Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility | Supplementary information

Focus onYear of the Rat

SNP and haplotype mapping for genetic analysis in the rat - pp560 - 566

The STAR Consortium

doi:10.1038/ng.124

First Paragraph - | Full Text - SNP and haplotype mapping for genetic analysis in the rat | PDF (332 KB) - SNP and haplotype mapping for genetic analysis in the rat | Supplementary information

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) - pp569 - 571

Karin E Finberg, Matthew M Heeney, Dean R Campagna, Yeim Aydnok, Howard A Pearson, Kip R Hartman, Mary M Mayo, Stewart M Samuel, John J Strouse, Kyriacos Markianos, Nancy C Andrews & Mark D Fleming

doi:10.1038/ng.130

Abstract - | Full Text - Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) | PDF (121 KB) - Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA) | Supplementary information

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis - pp572 - 574

Edor Kabashi, Paul N Valdmanis, Patrick Dion, Dan Spiegelman, Brendan J McConkey, Christine Vande Velde, Jean-Pierre Bouchard, Lucette Lacomblez, Ksenia Pochigaeva, Francois Salachas, Pierre-Francois Pradat, William Camu, Vincent Meininger, Nicolas Dupre & Guy A Rouleau

doi:10.1038/ng.132

Abstract - | Full Text - TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis | PDF (230 KB) - TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis | Supplementary information

Genome-wide association analysis identifies 20 loci that influence adult height - pp575 - 583

Michael N Weedon, Hana Lango, Cecilia M Lindgren, Chris Wallace, David M Evans, Massimo Mangino, Rachel M Freathy, John R B Perry, Suzanne Stevens, Alistair S Hall, Nilesh J Samani, Beverly Shields, Inga Prokopenko, Martin Farrall, Anna Dominiczak, Diabetes Genetics Initiative, The Wellcome Trust Case Control Consortium, Toby Johnson, Sven Bergmann, Jacques S Beckmann, Peter Vollenweider, Dawn M Waterworth, Vincent Mooser, Colin N A Palmer, Andrew D Morris, Willem H Ouwehand, Cambridge GEM Consortium, Mark Caulfield, Patricia B Munroe, Andrew T Hattersley, Mark I McCarthy & Timothy M Frayling

doi:10.1038/ng.121

Abstract - | Full Text - Genome-wide association analysis identifies 20 loci that influence adult height | PDF (329 KB) - Genome-wide association analysis identifies 20 loci that influence adult height | Supplementary information

See also: News and Views by Visscher | Article by Lettre et al. | Letter by Gudbjartsson et al.

Identification of ten loci associated with height highlights new biological pathways in human growth - pp584 - 591

Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, Serena Sanna, Susana Eyheramendy, Benjamin F Voight, Johannah L Butler, Candace Guiducci, Thomas Illig, Rachel Hackett, Iris M Heid, Kevin B Jacobs, Valeriya Lyssenko, Manuela Uda, The Diabetes Genetics Initiative, FUSION, KORA, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial, The Nurses' Health Study, SardiNIA, Michael Boehnke, Stephen J Chanock, Leif C Groop, Frank B Hu, Bo Isomaa, Peter Kraft, Leena Peltonen, Veikko Salomaa, David Schlessinger, David J Hunter, Richard B Hayes, Gonçalo R Abecasis, H-Erich Wichmann, Karen L Mohlke & Joel N Hirschhorn

doi:10.1038/ng.125

Abstract - | Full Text - Identification of ten loci associated with height highlights new biological pathways in human growth | PDF (347 KB) - Identification of ten loci associated with height highlights new biological pathways in human growth | Supplementary information

See also: News and Views by Visscher | Article by Weedon et al. | Letter by Gudbjartsson et al.

Rare independent mutations in renal salt handling genes contribute to blood pressure variation - pp592 - 599

Weizhen Ji, Jia Nee Foo, Brian J O'Roak, Hongyu Zhao, Martin G Larson, David B Simon, Christopher Newton-Cheh, Matthew W State, Daniel Levy & Richard P Lifton

doi:10.1038/ng.118

Abstract - | Full Text - Rare independent mutations in renal salt handling genes contribute to blood pressure variation | PDF (327 KB) - Rare independent mutations in renal salt handling genes contribute to blood pressure variation | Supplementary information

See also: News and Views by Devuyst

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon - pp600 - 608

Kevin M Haigis, Krystle R Kendall, Yufang Wang, Ann Cheung, Marcia C Haigis, Jonathan N Glickman, Michiko Niwa-Kawakita, Alejandro Sweet-Cordero, Judith Sebolt-Leopold, Kevin M Shannon, Jeffrey Settleman, Marco Giovannini & Tyler Jacks

doi:10.1038/ng.115

Abstract - | Full Text - Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon | PDF (922 KB) - Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon | Supplementary information

Many sequence variants affecting diversity of adult human height - pp609 - 615

Daniel F Gudbjartsson, G Bragi Walters, Gudmar Thorleifsson, Hreinn Stefansson, Bjarni V Halldorsson, Pasha Zusmanovich, Patrick Sulem, Steinunn Thorlacius, Arnaldur Gylfason, Stacy Steinberg, Anna Helgadottir, Andres Ingason, Valgerdur Steinthorsdottir, Elinborg J Olafsdottir, Gudridur H Olafsdottir, Thorvaldur Jonsson, Knut Borch-Johnsen, Torben Hansen, Gitte Andersen, Torben Jorgensen, Oluf Pedersen, Katja K Aben, J Alfred Witjes, Dorine W Swinkels, Martin den Heijer, Barbara Franke, Andre L M Verbeek, Diane M Becker, Lisa R Yanek, Lewis C Becker, Laufey Tryggvadottir, Thorunn Rafnar, Jeffrey Gulcher, Lambertus A Kiemeney, Augustine Kong, Unnur Thorsteinsdottir & Kari Stefansson

doi:10.1038/ng.122

First Paragraph - | Full Text - Many sequence variants affecting diversity of adult human height | PDF (220 KB) - Many sequence variants affecting diversity of adult human height | Supplementary information

See also: News and Views by Visscher | Article by Weedon et al. | Article by Lettre et al.

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 - pp616 - 622

Christopher I Amos, Xifeng Wu, Peter Broderick, Ivan P Gorlov, Jian Gu, Timothy Eisen, Qiong Dong, Qing Zhang, Xiangjun Gu, Jayaram Vijayakrishnan, Kate Sullivan, Athena Matakidou, Yufei Wang, Gordon Mills, Kimberly Doheny, Ya-Yu Tsai, Wei Vivien Chen, Sanjay Shete, Margaret R Spitz & Richard S Houlston

doi:10.1038/ng.109

First Paragraph - | Full Text - Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 | PDF (494 KB) - Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 | Supplementary information

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 - pp623 - 630

Ian PM Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Kimberley Howarth, Alan M Pittman, Sarah Spain, Steven Lubbe, Axel Walther, Kate Sullivan, Emma Jaeger, Sarah Fielding, Andrew Rowan, Jayaram Vijayakrishnan, Enric Domingo, Ian Chandler, Zoe Kemp, Mobshra Qureshi, Susan M Farrington, Albert Tenesa, James GD Prendergast, Rebecca A Barnetson, Steven Penegar, Ella Barclay, Wendy Wood, Lynn Martin, Maggie Gorman, Huw Thomas, Julian Peto, D Timothy Bishop, Richard Gray, Eamonn R Maher, Anneke Lucassen, David Kerr, D Gareth R Evans, The CORGI Consortium, Clemens Schafmayer, Stephan Buch, Henry Völzke, Jochen Hampe, Stefan Schreiber, Ulrich John, Thibaud Koessler, Paul Pharoah, Tom van Wezel, Hans Morreau, Juul T Wijnen, John L Hopper, Melissa C Southey, Graham G Giles, Gianluca Severi, Sergi Castellví-Bel, Clara Ruiz-Ponte, Angel Carracedo, Antoni Castells, The EPICOLON Consortium, Asta Försti, Kari Hemminki, Pavel Vodicka, Alessio Naccarati, Lara Lipton, Judy WC Ho, K K Cheng, Pak C Sham, J Luk, Jose AG Agúndez, Jose M Ladero, Miguel de la Hoya, Trinidad Caldés, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri Aaltonen, Jean-Baptiste Cazier, Harry Campbell, Malcolm G Dunlop & Richard S Houlston

doi:10.1038/ng.111

First Paragraph - | Full Text - A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 | PDF (336 KB) - A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 | Supplementary information

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 - pp631 - 637

Albert Tenesa, Susan M Farrington, James G D Prendergast, Mary E Porteous, Marion Walker, Naila Haq, Rebecca A Barnetson, Evropi Theodoratou, Roseanne Cetnarskyj, Nicola Cartwright, Colin Semple, Andrew J Clark, Fiona J L Reid, Lorna A Smith, Kostas Kavoussanakis, Thibaud Koessler, Paul D P Pharoah, Stephan Buch, Clemens Schafmayer, Jürgen Tepel, Stefan Schreiber, Henry Völzke, Carsten O Schmidt, Jochen Hampe, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Stefan Wilkening, Federico Canzian, Gabriel Capella, Victor Moreno, Ian J Deary, John M Starr, Ian P M Tomlinson, Zoe Kemp, Kimberley Howarth, Luis Carvajal-Carmona, Emily Webb, Peter Broderick, Jayaram Vijayakrishnan, Richard S Houlston, Gad Rennert, Dennis Ballinger, Laura Rozek, Stephen B Gruber, Koichi Matsuda, Tomohide Kidokoro, Yusuke Nakamura, Brent W Zanke, Celia M T Greenwood, Jagadish Rangrej, Rafal Kustra, Alexandre Montpetit, Thomas J Hudson, Steven Gallinger, Harry Campbell & Malcolm G Dunlop

doi:10.1038/ng.133

First Paragraph - | Full Text - Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 | PDF (255 KB) - Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 | Supplementary information

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes - pp638 - 645

Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul IW de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen, Kristin Ardlie, Kristina Bengtsson Boström, Richard N Bergman, Lori L Bonnycastle, Knut Borch-Johnsen, Noël P Burtt, Hong Chen, Peter S Chines, Mark J Daly, Parimal Deodhar, Chia-Jen Ding, Alex S F Doney, William L Duren, Katherine S Elliott, Michael R Erdos, Timothy M Frayling, Rachel M Freathy, Lauren Gianniny, Harald Grallert, Niels Grarup, Christopher J Groves, Candace Guiducci, Torben Hansen, Christian Herder, Graham A Hitman, Thomas E Hughes, Bo Isomaa, Anne U Jackson, Torben Jørgensen, Augustine Kong, Kari Kubalanza, Finny G Kuruvilla, Johanna Kuusisto, Claudia Langenberg, Hana Lango, Torsten Lauritzen, Yun Li, Cecilia M Lindgren, Valeriya Lyssenko, Amanda F Marvelle, Christa Meisinger, Kristian Midthjell, Karen L Mohlke, Mario A Morken, Andrew D Morris, Narisu Narisu, Peter Nilsson, Katharine R Owen, Colin NA Palmer, Felicity Payne, John R B Perry, Elin Pettersen, Carl Platou, Inga Prokopenko, Lu Qi, Li Qin, Nigel W Rayner, Matthew Rees, Jeffrey J Roix, Anelli Sandbæk, Beverley Shields, Marketa Sjögren, Valgerdur Steinthorsdottir, Heather M Stringham, Amy J Swift, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Nicholas J Timpson, Tiinamaija Tuomi, Jaakko Tuomilehto, Mark Walker, Richard M Watanabe, Michael N Weedon, Cristen J Willer, Wellcome Trust Case Control Consortium, Thomas Illig, Kristian Hveem, Frank B Hu, Markku Laakso, Kari Stefansson, Oluf Pedersen, Nicholas J Wareham, Inês Barroso, Andrew T Hattersley, Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke & David Altshuler

doi:10.1038/ng.120

First Paragraph - | Full Text - Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes | PDF (325 KB) - Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes | Supplementary information

Interpreting principal component analyses of spatial population genetic variation - pp646 - 649

John Novembre & Matthew Stephens

doi:10.1038/ng.139

First Paragraph - | Full Text - Interpreting principal component analyses of spatial population genetic variation | PDF (315 KB) - Interpreting principal component analyses of spatial population genetic variation | Supplementary information

See also: News and Views by Reich et al.

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas - pp650 - 655

Wen Qiu, Min Hu, Anita Sridhar, Ken Opeskin, Stephen Fox, Michail Shipitsin, Melanie Trivett, Ella R Thompson, Manasa Ramakrishna, Kylie L Gorringe, Kornelia Polyak, Izhak Haviv & Ian G Campbell

doi:10.1038/ng.117

First Paragraph - | Full Text - No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas | PDF (871 KB) - No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas | Supplementary information

See also: News and Views by Weinberg

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal T cells - pp656 - 662

Lynn M Boyden, Julia M Lewis, Susannah D Barbee, Anna Bas, Michael Girardi, Adrian C Hayday, Robert E Tigelaar & Richard P Lifton

doi:10.1038/ng.108

First Paragraph - | Full Text - Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal T cells | PDF (592 KB) - Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal T cells | Supplementary information

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation - pp663 - 669

Marnie E Blewitt, Anne-Valerie Gendrel, Zhenyi Pang, Duncan B Sparrow, Nadia Whitelaw, Jeffrey M Craig, Anwyn Apedaile, Douglas J Hilton, Sally L Dunwoodie, Neil Brockdorff, Graham F Kay & Emma Whitelaw

doi:10.1038/ng.142

First Paragraph - | Full Text - SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation | PDF (608 KB) - SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation | Supplementary information

A structural-maintenance-of-chromosomes hinge domain–containing protein is required for RNA-directed DNA methylation - pp670 - 675

Tatsuo Kanno, Etienne Bucher, Lucia Daxinger, Bruno Huettel, Gudrun Böhmdorfer, Wolfgang Gregor, David P Kreil, Marjori Matzke & Antonius J M Matzke

doi:10.1038/ng.119

First Paragraph - | Full Text - A structural-maintenance-of-chromosomes hinge domain–containing protein is required for RNA-directed DNA methylation | PDF (305 KB) - A structural-maintenance-of-chromosomes hinge domain–containing protein is required for RNA-directed DNA methylation | Supplementary information

Exposing the fitness contribution of duplicated genes - pp676 - 681

Alexander DeLuna, Kalin Vetsigian, Noam Shoresh, Matthew Hegreness, Maritrini Colón-González, Sharon Chao & Roy Kishony

doi:10.1038/ng.123

First Paragraph - | Full Text - Exposing the fitness contribution of duplicated genes | PDF (268 KB) - Exposing the fitness contribution of duplicated genes | Supplementary information

Erratum: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids - p682

Christopher C Park, Sangtae Ahn, Joshua S Bloom, Andy Lin, Richard T Wang, Tongtong Wu, Aswin Sekar, Arshad H Khan, Christine J Farr, Aldons J Lusis, Richard M Leahy, Kenneth Lange & Desmond J Smith

doi:10.1038/ng0508-682

Full Text - Erratum: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids | PDF (2,176 KB) - Erratum: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids