News and Views
Nature Genetics 41, 768 - 769 (2009)
doi:10.1038/ng0709-768
Tumors line up for a letdown
Joshua T Mendell1
-
Joshua T. Mendell is at the McKusick-Nathans Institute of Genetic Medicine and Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
e-mail: jmendell@jhmi.edu
Abstract
MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Cancer biomarker profiling with microRNAsNature Biotechnology News and Views (01 Apr 2008)
Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptationNature Structural & Molecular Biology News and Views (01 Jul 2007)
See all 3 matches for News And ViewsRESEARCH
Intensive conditioning regimen of etoposide (VP-16), cyclophosphamide and carmustine (VCB) followed by autologous hematopoietic stem cell transplantation for relapsed and refractory Hodgkin's lymphomaBone Marrow Transplantation Original Article
Emx2 patterns the neocortex by regulating FGF positional signalingNature Neuroscience Article (01 Aug 2003)
See all 5 matches for Research
