Nature Immunology - Current issue : January 2009 - Vol 10 No 1
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A major challenge for vaccinologists is to understand vaccine immunogenicity. Pulendran and colleagues use systems biology to determine gene 'signatures' that predict CD8+ T cell and antibody responses to the yellow fever vaccine.
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News & Views by Thomas & DohertyAdvance online publication
CD28 regulates PDK1
Article by ParkThe mechanism by which the coreceptor CD28 contributes to T cell activation is vague. Ghosh and colleagues find that CD28 facilitates NF-κB activation by regulating recruitment and phosphorylation of the kinase PDK1.
Advance online publication
Controlling inflammatory hypoxia
Article by RosenbergerHypoxia incites inflammation, particularly at mucosal surfaces. Eltzschig and colleagues show that hypoxia also suppresses inflammation by inducing expression of the neuronal guidance molecule netrin-1, which inhibits the transepithelial migration of neutrophils.
Advance online publication
Integrated dectin-1 signaling
Article by GringhuisThe C-type lectin dectin-1 induces T cell responses. Geijtenbeek and colleagues demonstrate that in human dendritc cells, dectin-1 ligands induce two independent signaling pathways that act in synergy at the point of activation of nuclear factor-κB.
Current issue
Cortical exits
Article by GrigorovaLymphocytes exit lymph nodes and return to the bloodstream through the efferent lymphatics. Cyster and colleagues show that lymphocytes exit into cortical sinuses by a pathway dependent on sphingosine 1-phosphate receptor type 1.
Announcement
Editorial position available
Nature Immunology seeks an Assistant Editor to join their editorial team. Applicants should have a PhD, a strong research background (preferably in T cell biology or innate immunity), broad interest in immunology, excellent literary skills, commitment to the communication of scientific ideas, and willingness and ability to learn new fields.
To apply, please submit a curriculum vitae, an editorial and a cover letter explaining your interest in the position to Human Resources Department, Nature Publishing Group, 75 Varick St., 9th Floor, New York, NY 10013-1917
E-mail: admin@natureny.com. Applications should arrive as soon as possible and no later than January 31st, 2009
