Nature Immunology
2, 108 - 115 (2001)
doi:10.1038/84209
Chemokines and diseaseCraig Gerard1
& Barrett J. Rollins21
Department of Pediatrics, Perlmutter Laboratory, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 2
Department of Adult Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Correspondence should be addressed to Craig Gerard gerard_c@gonzo.tch.harvard.edu or Barrett J. Rollins barrett_rollins@dfci.harvard.eduWe examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.
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