Giorgio Trinchieri is in the Laboratory for Immunological Research, Schering-Plough Research Institute, Dardilly, France. giorgio.trinchieri@spcorp.com
The ability of NKG2D to trigger costimulation in CD8+ T cells and cytotoxicity in NK cells is thought to arise from its differential association with the intracellular signaling molecules DAP10 and DAP12, respectively. This model has now been refined to include the ability of DAP10 to mediate cytotoxic signals.
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