Chromatin dynamics and locus accessibility in the immune system
Raul Mostoslavsky, Frederick W Alt
& Craig H Bassing
Howard Hughes Medical Institute, Children's Hospital, Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Development in vertebrates follows distinctive pathways of cellular differentiation. Starting from the zygote, newly formed cells continually differentiate until they reach a final mature fate. Whether differentiating into a neuron, a hepatocyte or a myofibril, every normal cell, with the exception of developing lymphocytes, carries the same genetic information enclosed within its nucleus. To acquire distinct cellular identities, cells need to control gene expression in a very regulated way. Genes encoding factors required for identity at a particular developmental stage need to be appropriately activated, whereas genes required for identity during the previous developmental stage are often silenced. Moreover, once a cell becomes terminally differentiated, 'heritable' gene expression must be maintained in all daughter cells and, thus, faithfully recapitulated after each cellular division.
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